Louilot A, Gonzalez-Mora J L, Guadalupe T, Mas M
Laboratoire de Psychobiologie des Comportements Adaptatifs, INSERM U.259, Université de Bordeaux II, France.
Brain Res. 1991 Jul 12;553(2):313-7. doi: 10.1016/0006-8993(91)90841-i.
Changes in the dopaminergic (DA) transmission in the nucleus accumbens were investigated in male rats exposed to sociosexual olfactory stimuli from different conspecifics: receptive female, non-receptive female and intact male. DAergic transmission was assessed by measurement of extracellular levels of DA and dihydroxyphenylacetic acid (DOPAC). Both compounds were recorded by using differential normal pulse voltammetry (DNPV) with electrochemically pretreated carbon fiber electrodes and numerical analysis of the catechol peak. Exposition to receptive female odors induced a marked and selective increase in DA release compared to control values. Exposition to non-receptive female odors and male odors induced an increase in DA release not significantly different from that following the change of environment. In conclusion, mesencephalic DAergic neurons reaching the nucleus accumbens appear to be involved in the perception of behaviorally significant olfactory cues.
研究了暴露于来自不同同种个体（处于接受状态的雌性、非接受状态的雌性和未阉割的雄性）的社会性行为嗅觉刺激下的雄性大鼠伏隔核中多巴胺能（DA）传递的变化。通过测量细胞外多巴胺（DA）和二羟基苯乙酸（DOPAC）水平来评估多巴胺能传递。使用经电化学预处理的碳纤维电极，通过差分正常脉冲伏安法（DNPV）记录这两种化合物，并对儿茶酚峰进行数值分析。与对照值相比，暴露于处于接受状态的雌性气味中会导致DA释放显著且选择性增加。暴露于非接受状态的雌性气味和雄性气味中会导致DA释放增加，与环境变化后的增加无显著差异。总之，投射到伏隔核的中脑多巴胺能神经元似乎参与了对行为上有重要意义的嗅觉线索的感知。
