Kendrick K M, Keverne E B, Hinton M R, Goode J A
A.F.R.C. Institute of Animal Physiology and Genetics Research, Cambridge Research Station, Babraham.
Brain Res Bull. 1991 May;26(5):803-7. doi: 10.1016/0361-9230(91)90178-m.
Simultaneous blood and cerebrospinal fluid (CSF) samples were taken from conscious sheep before, during and after parturition. Concentrations of plasma and CSF oxytocin were significantly elevated during contractions and particularly at birth. Mean prepartum CSF concentrations of oxytocin were around 55% of those found in plasma but postpartum they were up to 2-fold higher than those in plasma. Plasma concentrations of oxytocin were only significantly elevated, compared to prepartum levels, for 15 min postpartum whereas those in CSF were increased for the whole of the 120 min postpartum sampling period. Plasma, but not CSF, concentrations of arginine-vasopressin (AVP) were significantly raised during contractions and birth, and for 15 min postpartum. During the prepartum period CSF AVP concentrations were 67% of those found in plasma whereas at birth plasma levels were 10-fold higher than in CSF. In a separate experiment it was shown that 5 min of mechanical vaginocervical stimulation also stimulated significant increases in CSF and plasma oxytocin concentrations and in plasma vasopressin. Results support previous work suggesting an important role for central oxytocin release in the postpartum induction of maternal behavior and demonstrate that elevated concentrations of oxytocin in the CSF are present for a greater period than in blood. Elevated plasma AVP concentrations during contractions, birth or vaginocervical stimulation may be stimulated by stress associated with these stimuli.
在分娩前、分娩期间和分娩后，从清醒的绵羊身上同时采集血液和脑脊液（CSF）样本。在宫缩期间，尤其是在分娩时，血浆和脑脊液中催产素的浓度显著升高。产前脑脊液中催产素的平均浓度约为血浆中浓度的55%，但产后其浓度比血浆中浓度高出2倍。与产前水平相比，催产素的血浆浓度仅在产后15分钟显著升高，而脑脊液中的催产素浓度在产后120分钟的整个采样期内都有所增加。在宫缩和分娩期间以及产后15分钟，精氨酸加压素（AVP）的血浆浓度显著升高，但脑脊液中的浓度未升高。在产前阶段，脑脊液中AVP的浓度为血浆中浓度的67%，而在出生时，血浆水平比脑脊液高10倍。在另一项实验中发现，5分钟的机械性阴道宫颈刺激也会显著增加脑脊液和血浆中催产素的浓度以及血浆中加压素的浓度。这些结果支持了先前的研究工作，表明中枢催产素释放对产后母性行为的诱导具有重要作用，并证明脑脊液中催产素浓度升高的持续时间比血液中更长。宫缩、分娩或阴道宫颈刺激期间血浆中AVP浓度升高可能是由与这些刺激相关的应激所引起的。
