骨髓增生异常综合征病理生理学中的自身免疫机制及其临床相关性。
Autoimmune mechanisms in the pathophysiology of myelodysplastic syndromes and their clinical relevance.
作者信息
Barrett A John, Sloand Elaine
机构信息
Stem Cell Allotransplantation Section, Hematology Branch, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
出版信息
Haematologica. 2009 Apr;94(4):449-51. doi: 10.3324/haematol.2009.006080.
Abstract
Accumulating evidence has shown that marrow failure in some patients with myelodysplastic syndrome is associated with autoimmunity, T-cell mediated myelosuppression and cytokine-induced cytopenias. In this perspective article, Drs. Barrett and Sloand expound on auto-immunity in myelodysplastic syndromes, in particular focusing on what has been learned from study of patients with trisomy 8. See related article on page 496.
摘要
越来越多的证据表明，一些骨髓增生异常综合征患者的骨髓衰竭与自身免疫、T细胞介导的骨髓抑制以及细胞因子诱导的血细胞减少有关。在这篇观点文章中，巴雷特博士和斯隆德博士阐述了骨髓增生异常综合征中的自身免疫，尤其着重介绍了对8号三体综合征患者研究的所得。见第496页相关文章。
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