Inserm-EPHE-Université de Caen/Basse-Normandie, Unité U923, GIP Cyceron, CHU Côte de Nacre, Caen, France.
Hippocampus. 2010 Jan;20(1):153-65. doi: 10.1002/hipo.20601.
We previously demonstrated that episodic autobiographical memories (EAMs) rely on a network of brain regions comprising the medial temporal lobe (MTL) and distributed neocortical regions regardless of their remoteness. The findings supported the model of memory consolidation, which proposes a permanent role of MTL during EAM retrieval (multiple-trace theory or MTT) rather than a temporary role (standard model). Our present aim was to expand the results by examining the interactions between the MTL and neocortical regions (or MTL-neocortical links) during EAM retrieval with varying retention intervals. We used an experimental paradigm specially designed to engage aged participants in the recollection of EAMs, extracted from five different time-periods, covering their whole life-span, in order to examine correlations between activation in the MTL and neocortical regions. The nature of the memories was checked at debriefing by means of behavioral measures to control the degree of episodicity and properties of memories. Targeted correlational analyses carried out on the MTL, frontal, lateral temporal, and posterior regions revealed strong links between the MTL and neocortex during the retrieval of both recent and remote EAMs, challenging the standard model of memory consolidation and supporting MTT instead. Further confirmation was given by results showing that activation in the left and right hippocampi significantly correlated during the retrieval of both recent and remote memories. Correlations among extra-MTL neocortical regions also emerged for all time-periods, confirming the critical role of the prefrontal, temporal (lateral temporal cortex and temporal pole), precuneus, and posterior cingulate regions in EAM retrieval. Overall, this paper emphasizes the role of a bilateral network of MTL and neocortical areas whose activation correlate during the recollection of rich phenomenological recent and remote EAMs.
我们之前的研究表明，情景自传体记忆（EAMs）依赖于一个由内侧颞叶（MTL）和分布的新皮质区域组成的网络，无论其距离远近如何。这些发现支持了记忆巩固模型，该模型提出了 MTL 在 EAM 检索过程中的永久性作用（多轨迹理论或 MTT），而不是临时性作用（标准模型）。我们目前的目的是通过检查在不同保留间隔下 EAM 检索过程中 MTL 和新皮质区域（或 MTL-新皮质连接）之间的相互作用来扩展结果。我们使用了一种专门设计的实验范式，使老年参与者参与从五个不同时间段提取的情景自传体记忆的回忆，以检查 MTL 和新皮质区域之间的激活之间的相关性。在询问过程中通过行为测量来检查记忆的性质，以控制情节性和记忆的特性。在 MTL、额叶、外侧颞叶和后叶区域上进行的有针对性的相关分析表明，在检索近期和远期 EAMs 时，MTL 和新皮质之间存在很强的联系，这挑战了记忆巩固的标准模型，并支持 MTT 取而代之。结果表明，在检索近期和远期记忆时，左、右海马体的激活显著相关，进一步证实了这一观点。在所有时间段，MTL 以外的新皮质区域之间也出现了相关性，这证实了前额叶、颞叶（外侧颞叶皮质和颞极）、楔前叶和后扣带回区域在 EAM 检索中的关键作用。总的来说，本文强调了双侧 MTL 和新皮质区域网络的作用，在回忆丰富的现象学近期和远期 EAMs 时，这些区域的激活相互关联。
