Cognitive and Motor Rehabilitation and Neuroimaging Unit, IRCCS Fondazione Santa Lucia, Rome, Italy.
Cognitive and Motor Rehabilitation and Neuroimaging Unit, IRCCS Fondazione Santa Lucia, Rome, Italy; Department of Psychology, "Sapienza" University of Rome, PhD Program in Behavioral Neuroscience, Rome, Italy.
Neurosci Biobehav Rev. 2019 Dec;107:84-95. doi: 10.1016/j.neubiorev.2019.09.003. Epub 2019 Sep 3.
Episodic autobiographical memory (EAM) is pivotal for the development and maintenance of personal identity. However, a theoretical debate still exists about where EAMs are stored in our brain and about hippocampal unique contribution to their recollection. Here we disentangled this issue performing an Activation Likelihood Estimation (ALE) meta-analysis on 79 neuroimaging experiments, classified according to the remoteness of EAMs, and meta-analytic connectivity modeling. A wide brain network, spanning from occipital to frontal lobe, was involved in recalling EAMs. However, remote and recent EAMs were processed by different nodes of this network: recent EAMs activated angular gyrus, dorsomedial prefrontal cortex and hippocampus/parahippocampal gyrus, that we found to be connected with its contralateral homologous, bilateral middle cingulate cortex, left inferior frontal gyrus and left superior parietal lobule. Instead, remote EAMs activated posterior cingulate cortex, that we found to be connected with hippocampus/parahippocampal gyrus. These results provide new important evidence for the theoretical discussion about where and how EAMs are stored in the brain and new exciting insights into hippocampal contribution to EAM.
情景自传记忆（EAM）对于个人身份的发展和维持至关重要。然而，关于 EAM 在我们大脑中的存储位置以及海马体对其回忆的独特贡献，仍存在理论上的争议。在这里，我们通过对 79 项神经影像学实验进行激活似然估计（ALE）荟萃分析，并根据 EAM 的遥远程度进行分类，来解决这个问题，同时还进行了荟萃分析连接建模。一个从枕叶到额叶的广泛脑网络参与了回忆 EAM。然而，远程和近期的 EAM 是由这个网络的不同节点处理的：近期的 EAM 激活了角回、背内侧前额叶皮质和海马/旁海马回，我们发现它们与对侧同源、双侧扣带回中部、左侧额下回和左侧顶上小叶相连。相反，远程 EAM 激活了后扣带回，我们发现它与海马/旁海马回相连。这些结果为关于 EAM 在大脑中的存储位置和存储方式的理论讨论提供了新的重要证据，也为海马体对 EAM 的贡献提供了新的令人兴奋的见解。
