Hawkins J M, Craig J M, Secker-Walker L M, Prentice H G, Mehta A B
Cytogenetics, Royal Free Hospital Medical School, London, UK.
Cancer Genet Cytogenet. 1991 Sep;55(2):157-62. doi: 10.1016/0165-4608(91)90072-3.
Chromosome analysis of bone marrow cells from a patient with acute nonlymphocytic leukemia M2 revealed the translocation t(11;22)(q24;q12) usually associated with Ewing's sarcoma. Molecular investigations ruled out the possibility that this was a variant Philadelphia translocation with breakpoints in the major breakpoint cluster region. Although cytogenetic analysis was not available at diagnosis, this abnormality was found both pre- and postallogeneic bone marrow transplant.
一名急性非淋巴细胞白血病M2患者的骨髓细胞染色体分析显示存在通常与尤因肉瘤相关的t(11;22)(q24;q12)易位。分子研究排除了这是一种在主要断裂点簇区域有断点的变异费城易位的可能性。尽管诊断时无法进行细胞遗传学分析，但在异基因骨髓移植前后均发现了这种异常。
