Yip Kai-Tai, Zhu Nian-Yong, Yang Dan
Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, PR China.
Org Lett. 2009 May 7;11(9):1911-4. doi: 10.1021/ol900355h.
Isoquinoline and quinoline have been discovered as novel ligands for palladium-catalyzed oxidative cascade cyclization reactions. With our new catalyst systems (Pd(OAc)(2)/isoquinoline or quinoline), unsaturated anilides cyclize under an oxygen atmosphere (1 atm) to furnish structurally versatile indoline derivatives in good yields. One C-N bond and two C-C bonds are formed in a single step with excellent diastereoselectivities (dr > 24:1).
异喹啉和喹啉已被发现是钯催化氧化级联环化反应的新型配体。使用我们的新催化剂体系（醋酸钯/异喹啉或喹啉），不饱和酰胺在氧气气氛（1个大气压）下环化，以良好的产率提供结构多样的二氢吲哚衍生物。一步形成一个C-N键和两个C-C键，具有优异的非对映选择性（dr>24:1）。
