Ait-Oufella Hafid, Taleb Soraya, Mallat Ziad, Tedgui Alain
Paris Cardiovascular Research Center, INSERM and Assistance Publique-Hôpitaux de Paris, Hôpital Européen Georges Pompidou, 75015, Paris, France.
Semin Immunopathol. 2009 Jun;31(1):23-33. doi: 10.1007/s00281-009-0143-x. Epub 2009 Apr 2.
Atherosclerosis is a chronic inflammatory disease of the arterial wall where both innate and adaptive immune responses contribute to disease initiation and progression. Recent studies established that subtypes of T cells, regulatory T cells (Tregs), actively involved in the maintenance of immunological tolerance, inhibit the development and progression of atherosclerosis. Here, we review the current knowledge on the Treg response and the major cytokines involved in its modulation in the context of atherosclerosis.
动脉粥样硬化是一种动脉壁的慢性炎症性疾病，固有免疫反应和适应性免疫反应均参与疾病的发生和发展。最近的研究证实，积极参与维持免疫耐受的T细胞亚型——调节性T细胞（Tregs），可抑制动脉粥样硬化的发生和发展。在此，我们综述了目前关于调节性T细胞反应以及在动脉粥样硬化背景下参与其调节的主要细胞因子的相关知识。
