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竹荪子实体多糖组分的促有丝分裂和集落刺激因子诱导活性

Mitogenic and colony-stimulating factor-inducing activities of polysaccharide fractions from the fruit bodies of Dictyophora indusiata Fisch.

作者信息

Hara C, Kumazawa Y, Inagaki K, Kaneko M, Kiho T, Ukai S

机构信息

Shotoku Gakuen Women's Junior College, Gifu, Japan.

出版信息

Chem Pharm Bull (Tokyo). 1991 Jun;39(6):1615-6. doi: 10.1248/cpb.39.1615.

DOI:10.1248/cpb.39.1615
PMID:1934185
Abstract

Biological effects (mitogenic and colony-stimulating factor (CSF)-inducing activities) of five homogeneous polysaccharides and a conjugated polysaccharide fraction isolated from the fruit bodies of Dictyophora indusiata Fisch. were investigated. Fucomammogalactan (T-3-Ad) and conjugated polysaccharide fraction (T-2-A) exhibited significant mitogenic and CSF-inducing activities. Among two beta-(1----6)-branched (1----3)-beta-D-glucans (T-4-N and T-5-N), only T-4-N showed both mitogenic and CSF-inducing effects. Partially O-acetylated (1----3)-alpha-D-mannans (T-2-HN and T-3-M') did not show these effects.

摘要

研究了从竹荪子实体中分离得到的五种均一多糖和一种结合多糖组分的生物学效应(促有丝分裂和集落刺激因子(CSF)诱导活性)。岩藻乳甘露聚糖(T-3-Ad)和结合多糖组分(T-2-A)表现出显著的促有丝分裂和CSF诱导活性。在两种β-(1→6)分支的(1→3)-β-D-葡聚糖(T-4-N和T-5-N)中,只有T-4-N同时表现出促有丝分裂和CSF诱导作用。部分O-乙酰化的(1→3)-α-D-甘露聚糖(T-2-HN和T-3-M')未表现出这些效应。

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