Busse W W
Am Rev Respir Dis. 1977 May;115(5):783-91. doi: 10.1164/arrd.1977.115.5.783.
Isoproterenol inhibits zymosan-stimulated release of lysosomal enzymes from granulocytes. Using this as an in vitro cell model to study beta-adrenergic response, granulocyte reaction to isoproterenol was examined in asthma. There was a significantly decreased response to isoproterenol (10(-7) to 10(+-5) M) in patients with mild asthma who had not taken bronchodilators for 2 weeks before study and also in patients with severe asthma requiring bronchodilators and corticosteroids. During respiratory infections that provoked an attack of asthma, the granulocyte response to isoproterenol was further decreased. The change in granulocyte response to isoproterenol may reflect a similar change in beta-adrenergic tone of the airways and provide one explanation for asthma during colds.
异丙肾上腺素可抑制酵母聚糖刺激的粒细胞溶酶体酶释放。以这作为体外细胞模型来研究β-肾上腺素能反应，在哮喘中检测了粒细胞对异丙肾上腺素的反应。在研究前2周未服用支气管扩张剂的轻度哮喘患者以及需要支气管扩张剂和皮质类固醇的重度哮喘患者中，对异丙肾上腺素（10⁻⁷至10⁻⁵M）的反应均显著降低。在引发哮喘发作的呼吸道感染期间，粒细胞对异丙肾上腺素的反应进一步降低。粒细胞对异丙肾上腺素反应的变化可能反映气道β-肾上腺素能张力的类似变化，并为感冒期间的哮喘提供一种解释。
