巨细胞病毒临床分离株对人干扰素的敏感性
Susceptibility of clinical isolates of cytomegalovirus to human interferon.
作者信息
Postic B, Dowling J N
出版信息
Antimicrob Agents Chemother. 1977 Apr;11(4):656-60. doi: 10.1128/AAC.11.4.656.
Abstract
Human cell culture-derived interferon was shown to inhibit human cytomegalovirus in vitro. A prototype strain, Davis, and six clinical isolates of cytomegalovirus were tested. All six isolates showed uniform susceptibility to interferon, exceeding that of the Davis strain by two- to fourfold. The latter virus was found to be 32 to 4 times less susceptible than the sensitive indicator, vesicular stomatitis virus. However, the laboratory finding of susceptibility to an antiviral material may not relate to its clinical effectiveness.
摘要
人细胞培养衍生的干扰素在体外显示出对人巨细胞病毒有抑制作用。对一株原型毒株戴维斯株以及六株巨细胞病毒临床分离株进行了测试。所有六株分离株对干扰素均表现出一致的敏感性，比戴维斯株高出两到四倍。发现后一种病毒的敏感性比敏感指示病毒水疱性口炎病毒低32至4倍。然而，实验室中抗病毒物质敏感性的发现可能与其临床有效性无关。
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