克隆的和天然的人干扰素对1型和2型单纯疱疹病毒以及人巨细胞病毒的抗病毒活性比较。
Comparison of antiviral activities of cloned and native human interferons against herpes simplex virus types 1 and 2 and human cytomegalovirus.
作者信息
Rasmussen L E, Chen P T, Merigan T C
出版信息
Antimicrob Agents Chemother. 1984 Oct;26(4):599-600. doi: 10.1128/AAC.26.4.599.
Abstract
Five recombinant alpha interferons and two recombinant beta interferons have been tested for their ability to inhibit yields of herpes simplex virus types 1 and 2 and human cytomegalovirus in human embryonic lung cells. All of the alpha species and both of the beta forms (cysteine and serine) were active against the herpesviruses tested in this study. Neither the recombinant alpha nor the recombinant beta interferons exceeded the activity of the native species against herpes simplex viruses types 1 and 2. However, the recombinant beta interferons inhibited cytomegalovirus more than either the native beta or the alpha interferon species with the exception of interferon alpha K (alpha 6).
摘要
对五种重组α干扰素和两种重组β干扰素进行了测试，以考察它们在人胚肺细胞中抑制1型和2型单纯疱疹病毒以及人巨细胞病毒产生的能力。所有的α型干扰素以及两种β型干扰素（半胱氨酸型和丝氨酸型）对本研究中测试的疱疹病毒均有活性。重组α干扰素和重组β干扰素对1型和2型单纯疱疹病毒的活性均未超过天然干扰素。然而，除了干扰素αK（α6）外，重组β干扰素对巨细胞病毒的抑制作用比天然β干扰素或α干扰素更强。
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本文引用的文献
1
Antiviral activities of cloned human leukocyte interferons against herpes simplex virus type 2 infections of mice.
J Gen Virol. 1983 Oct;64 (Pt 10):2317-21. doi: 10.1099/0022-1317-64-10-2317.
2
Human leukocyte interferon subtypes have different antiproliferative and antiviral activities on human cells.
Biochem Biophys Res Commun. 1983 Apr 29;112(2):537-46. doi: 10.1016/0006-291x(83)91498-5.
3
Murine monoclonal antibody to a single protein neutralizes the infectivity of human cytomegalovirus.针对单一蛋白质的鼠单克隆抗体可中和人巨细胞病毒的感染性。
Proc Natl Acad Sci U S A. 1984 Feb;81(3):876-80. doi: 10.1073/pnas.81.3.876.
5
Drug therapy. Treatment of herpesvirus infections.药物治疗。疱疹病毒感染的治疗。
N Engl J Med. 1983 Oct 20;309(16):963-70. doi: 10.1056/NEJM198310203091607.
6
The human fibroblast and human immune interferon genes and their expression in homologous and heterologous cells.人类成纤维细胞和人类免疫干扰素基因及其在同源和异源细胞中的表达。
Philos Trans R Soc Lond B Biol Sci. 1982 Sep 24;299(1094):29-38. doi: 10.1098/rstb.1982.0103.
7
Comparison of the antiviral activities of various cloned human interferon-alpha subtypes in mammalian cell cultures.多种克隆的人α干扰素亚型在哺乳动物细胞培养物中的抗病毒活性比较。
J Gen Virol. 1981 Nov;57(Pt 1):233-7. doi: 10.1099/0022-1317-57-1-233.
8
Structure and expression of human IFN-alpha genes.人类干扰素-α基因的结构与表达
Philos Trans R Soc Lond B Biol Sci. 1982 Sep 24;299(1094):7-28. doi: 10.1098/rstb.1982.0102.
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J Gen Virol. 1977 Jun;35(3):573-7. doi: 10.1099/0022-1317-35-3-573.
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