Rasmussen L E, Chen P T, Merigan T C
Antimicrob Agents Chemother. 1984 Oct;26(4):599-600. doi: 10.1128/AAC.26.4.599.
Five recombinant alpha interferons and two recombinant beta interferons have been tested for their ability to inhibit yields of herpes simplex virus types 1 and 2 and human cytomegalovirus in human embryonic lung cells. All of the alpha species and both of the beta forms (cysteine and serine) were active against the herpesviruses tested in this study. Neither the recombinant alpha nor the recombinant beta interferons exceeded the activity of the native species against herpes simplex viruses types 1 and 2. However, the recombinant beta interferons inhibited cytomegalovirus more than either the native beta or the alpha interferon species with the exception of interferon alpha K (alpha 6).
对五种重组α干扰素和两种重组β干扰素进行了测试，以考察它们在人胚肺细胞中抑制1型和2型单纯疱疹病毒以及人巨细胞病毒产生的能力。所有的α型干扰素以及两种β型干扰素（半胱氨酸型和丝氨酸型）对本研究中测试的疱疹病毒均有活性。重组α干扰素和重组β干扰素对1型和2型单纯疱疹病毒的活性均未超过天然干扰素。然而，除了干扰素αK（α6）外，重组β干扰素对巨细胞病毒的抑制作用比天然β干扰素或α干扰素更强。
