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用外源性干扰素、聚肌苷酸-聚胞苷酸以及聚肌苷酸-聚胞苷酸-聚-L-赖氨酸复合物治疗小鼠巨细胞病毒感染。

Treatment of a murine cytomegalovirus infection with exogenous interferon, polyinosinic-polycytidylic acid, and polyinosinic-polycytidylic acid-poly-L-lysine complex.

作者信息

Kern E R, Olsen G A, Overall J C, Glasgow L A

出版信息

Antimicrob Agents Chemother. 1978 Feb;13(2):344-6. doi: 10.1128/AAC.13.2.344.

DOI:10.1128/AAC.13.2.344
PMID:206203
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC352239/
Abstract

Treatment of a cytomegalovirus infection of mice with exogenous murine interferon did not alter final mortality or mean day of death. Pretreatment with two interferon inducers significantly reduced mortality, but treatment initiated after infection was not effective.

摘要

用外源性鼠干扰素治疗小鼠巨细胞病毒感染，并未改变最终死亡率或平均死亡日。用两种干扰素诱导剂进行预处理可显著降低死亡率，但在感染后开始治疗则无效。

相似文献

1
Treatment of a murine cytomegalovirus infection with exogenous interferon, polyinosinic-polycytidylic acid, and polyinosinic-polycytidylic acid-poly-L-lysine complex.用外源性干扰素、聚肌苷酸-聚胞苷酸以及聚肌苷酸-聚胞苷酸-聚-L-赖氨酸复合物治疗小鼠巨细胞病毒感染。
Antimicrob Agents Chemother. 1978 Feb;13(2):344-6. doi: 10.1128/AAC.13.2.344.
2
Effect of treatment with exogenous interferon, polyinosinic acid-polyctyidylic acid or polyinosinic acid-polycytidylic acid-poly-L-lysine complex on encephalomyocarditis virus infections in mice.外源性干扰素、聚肌苷酸-聚胞苷酸或聚肌苷酸-聚胞苷酸-聚-L-赖氨酸复合物治疗对小鼠脑心肌炎病毒感染的影响。
Antimicrob Agents Chemother. 1976 Oct;10(4):668-76. doi: 10.1128/AAC.10.4.668.
3
Effect of treatment with exogenous interferon, polyriboinosinic-polyribocytidylic acid, or polyriboinosinic-polyribocytidylic acid-poly-L-lysine complex on Herpesvirus hominis infections in mice.外源性干扰素、聚肌苷酸-聚胞苷酸或聚肌苷酸-聚胞苷酸-聚-L-赖氨酸复合物治疗对小鼠人疱疹病毒感染的影响。
J Infect Dis. 1978 Apr;137(4):428-36. doi: 10.1093/infdis/137.4.428.
4
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Cancer Res. 1985 Mar;45(3):1066-72.
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Protection against murine cytomegalovirus infection in aged mice and mice with severe combined immunodeficiency disease with the biological response modifiers polyribosinic-polycytidylic acid stabilized with L-lysine and carboxymethylcellulose, maleic anhydride divinyl ether and colony stimulating factor 1.
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Cancer Treat Rep. 1986 Nov;70(11):1341-2.
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[Effect of a modified polyinosinic acid--polycytidylic acid complex against herpes simplex keratitis in monkeys (author's transl)].[一种改良的聚肌苷酸-聚胞苷酸复合物对猴单纯疱疹性角膜炎的作用（作者译）]
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Poly ICLC inhibits Plasmodium cynomolgi B malaria infection in rhesus monkeys.聚肌胞苷酸抑制恒河猴感染食蟹猴疟原虫B型疟疾。
J Interferon Cytokine Res. 1996 Jan;16(1):49-52. doi: 10.1089/jir.1996.16.49.
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J Biol Response Mod. 1985 Oct;4(5):475-80.

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Modulation of host innate and adaptive immune defenses by cytomegalovirus: timing is everything.巨细胞病毒对宿主固有和适应性免疫防御的调节：时机就是一切。
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J Virol. 2007 Jan;81(1):332-48. doi: 10.1128/JVI.01592-06. Epub 2006 Oct 25.
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Effects of immunosuppression with cyclophosphamide on acute murine cytomegalovirus infection and virus-augmented natural killer cell activity.环磷酰胺免疫抑制对急性小鼠巨细胞病毒感染及病毒增强的自然杀伤细胞活性的影响。
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Br J Exp Pathol. 1982 Dec;63(6):625-32.
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本文引用的文献

1
Sensitivity of Types 1 and 2 Herpesvirus hominis to an Interferon Inducer, Poly I:C.人单纯疱疹病毒 1 型和 2 型对干扰素诱导剂聚肌胞苷酸的敏感性。
Infect Immun. 1971 Jun;3(6):847-8. doi: 10.1128/iai.3.6.847-848.1971.
2
Interferon and cytomegalovirus in vivo and in vitro.体内和体外的干扰素与巨细胞病毒
Proc Soc Exp Biol Med. 1967 Jul;125(3):843-9. doi: 10.3181/00379727-125-32220.
3
Further studies on an inhibitor of viral activity appearing in infected cell cultures and its role in chronic viral infections.关于感染细胞培养物中出现的病毒活性抑制剂及其在慢性病毒感染中作用的进一步研究。
Virology. 1959 Nov;9:446-77. doi: 10.1016/0042-6822(59)90135-7.
4
Late therapy with an interferon stimulator in an arbovirus encephalitis in mice.在小鼠虫媒病毒脑炎中使用干扰素刺激剂进行晚期治疗。
Proc Soc Exp Biol Med. 1971 Jan;136(1):323-7. doi: 10.3181/00379727-136-35257.
5
Herpesvirus hominis infection in newborn mice. I. An experimental model and therapy with iododeoxyuridine.新生小鼠的人疱疹病毒感染。I. 一种实验模型及碘脱氧尿苷治疗法。
J Infect Dis. 1973 Sep;128(3):290-9. doi: 10.1093/infdis/128.3.290.
6
Herpesvirus hominis infection in newborn mice: treatment with interferon inducer polyinosinic-polycytidylic acid.新生小鼠人疱疹病毒感染：用干扰素诱导剂聚肌苷酸-聚胞苷酸进行治疗。
Antimicrob Agents Chemother. 1975 Jun;7(6):793-800. doi: 10.1128/AAC.7.6.793.
7
Effect of interferon on systemic herpesvirus infections.
Tex Rep Biol Med. 1977;35:472-7.
8
Susceptibility of clinical isolates of cytomegalovirus to human interferon.巨细胞病毒临床分离株对人干扰素的敏感性
Antimicrob Agents Chemother. 1977 Apr;11(4):656-60. doi: 10.1128/AAC.11.4.656.
9
Effect of treatment with exogenous interferon, polyinosinic acid-polyctyidylic acid or polyinosinic acid-polycytidylic acid-poly-L-lysine complex on encephalomyocarditis virus infections in mice.外源性干扰素、聚肌苷酸-聚胞苷酸或聚肌苷酸-聚胞苷酸-聚-L-赖氨酸复合物治疗对小鼠脑心肌炎病毒感染的影响。
Antimicrob Agents Chemother. 1976 Oct;10(4):668-76. doi: 10.1128/AAC.10.4.668.
10
Effective antiviral chemotherapy in cytomegalovirus infection of mice.
J Infect Dis. 1976 Jun;133 Suppl:A237-44. doi: 10.1093/infdis/133.supplement_2.a237.