Peters A M, Jäger F S, Warneke A, Müller K, Brunkhorst U, Schedel I, Gahr M
Department of Pediatrics, University Hospital, University of Göttingen, West Germany.
Clin Immunol Immunopathol. 1991 Dec;61(3):343-52. doi: 10.1016/s0090-1229(05)80006-6.
We have measured the production of interleukin 1 (IL 1), interleukin 6 (IL 6), and tumor necrosis factor alpha (TNF alpha) by unstimulated monocytes and monocytes stimulated with lipopolysaccharide (LPS) isolated from the peripheral blood of patients infected with human immunodeficiency virus 1 (HIV-1) and healthy controls. Spontaneous and LPS-induced cytokine production were not significantly different between patients and controls. Median lipopolysaccharide-stimulated cytokine secretion for patients and controls was 1.7 and 4.3 U/ml for IL 1, 475 and 625 U/ml for IL 6, and 468 and 580 pg/ml for TNF alpha. Cytokine levels were not related to stage of disease. We conclude that in vivo HIV infection itself does not alter peripheral blood monocyte cytokine secretion.
我们检测了来自感染人类免疫缺陷病毒1型（HIV-1）患者和健康对照者外周血中未受刺激的单核细胞以及经脂多糖（LPS）刺激的单核细胞产生白细胞介素1（IL-1）、白细胞介素6（IL-6）和肿瘤坏死因子α（TNF-α）的情况。患者和对照者之间自发和LPS诱导的细胞因子产生没有显著差异。患者和对照者经脂多糖刺激后的细胞因子分泌中位数，IL-1分别为1.7和4.3 U/ml，IL-6分别为475和625 U/ml，TNF-α分别为468和580 pg/ml。细胞因子水平与疾病阶段无关。我们得出结论，体内HIV感染本身不会改变外周血单核细胞的细胞因子分泌。
