Department of Diagnostic and Interventional Radiology, University Hospital (RWTH) Aachen, Pauwelsstrasse, Aachen, Germany.
Eur J Radiol. 2010 Mar;73(3):688-93. doi: 10.1016/j.ejrad.2009.01.008. Epub 2009 Apr 5.
To evaluate the influence of different saline chaser volumes and different saline chaser flow rates on the intravascular contrast enhancement in MDCT.
In a physiological flow phantom contrast medium (120 ml, 300 mgI/ml, Ultravist 300) was administered at a flow rate of 6 ml/s followed by different saline chaser volumes (0, 30, 60 and 90 ml) at the same injection rate or followed by a 30-ml saline chaser at different injection rates (2, 4, 6 and 8 ml/s). Serial CT-scans at a level covering the pulmonary artery, the ascending and the descending aorta replica were obtained. Time-enhancement curves were computed and both pulmonary and aortic peak enhancement and peak time were determined.
Compared to contrast medium injection without a saline chaser the pushing with a saline chaser (30, 60, and 90 ml) resulted in a statistically significant increased pulmonary peak enhancement (all p=0.008) and prolonged peak time (p=0.032, p=0.024 and p=0.008, respectively). Highest aortic peak enhancement values were detected for a saline chaser volume of 30 ml. A saline chaser flow rate of 8 ml/s resulted in the highest pulmonary peak enhancement values compared to flow rates of 2, 4 and 6 ml/s (all p=0.008). Aortic peak enhancement showed the highest values for a flow rate of 6 ml/s.
A saline chaser volume of 30 ml and an injection rate of 6 ml/s are sufficient to best improve vascular contrast enhancement in the pulmonary artery and the aorta in MDCT.
评估不同生理盐水冲洗量和不同生理盐水冲洗流速对 MDCT 血管内对比增强的影响。
在生理流动模型中，以 6ml/s 的流速注入造影剂（120ml，300mgI/ml，Ultravist 300），然后分别以相同的注射速率注入 0、30、60 和 90ml 的生理盐水冲洗剂，或者以不同的注射速率（2、4、6 和 8ml/s）注入 30ml 的生理盐水冲洗剂。在涵盖肺动脉、升主动脉和降主动脉复制品的水平上获取连续 CT 扫描。计算时间增强曲线，并确定肺动脉和主动脉峰值增强和峰值时间。
与不使用生理盐水冲洗剂的造影剂注射相比，使用生理盐水冲洗剂（30、60 和 90ml）推注可显著增加肺动脉峰值增强（均 p=0.008）和延长峰值时间（p=0.032、p=0.024 和 p=0.008）。检测到的最高主动脉峰值增强值是在使用 30ml 生理盐水冲洗剂时。与 2、4 和 6ml/s 的流速相比，8ml/s 的生理盐水冲洗流速可获得最高的肺动脉峰值增强值（均 p=0.008）。主动脉峰值增强的最高值出现在流速为 6ml/s 时。
30ml 生理盐水冲洗剂和 6ml/s 的注射速率足以在 MDCT 中最佳改善肺动脉和主动脉的血管对比增强。
