Harville Heather M, Voorman Richard, Prusakiewicz Jeffery J
Department of Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Rd., Ann Arbor, MI 48105, USA.
Drug Metab Lett. 2007 Jan;1(1):17-21. doi: 10.2174/187231207779814300.
Parabens are widely used preservatives in topical products, and are estrogenic in numerous experimental models. The typical cutaneous metabolism model, rat skin, hydrolyzes parabens much faster than human skin. Chronic application and absorption of parabens, combined with low metabolism rates, may lead to prolonged estrogenic effects in the skin.
对羟基苯甲酸酯是局部用产品中广泛使用的防腐剂，在众多实验模型中具有雌激素活性。典型的皮肤代谢模型——大鼠皮肤，对羟基苯甲酸酯的水解速度比人类皮肤快得多。对羟基苯甲酸酯的长期应用和吸收，再加上低代谢率，可能会导致皮肤中雌激素作用的延长。
