Bossi Alice, Lehner Ben
EMBL-CRG Systems Biology Unit, Centre for Genomic Regulation, UPF, Barcelona, Spain.
Mol Syst Biol. 2009;5:260. doi: 10.1038/msb.2009.17. Epub 2009 Apr 7.
A protein interaction network describes a set of physical associations that can occur between proteins. However, within any particular cell or tissue only a subset of proteins is expressed and so only a subset of interactions can occur. Integrating interaction and expression data, we analyze here this interplay between protein expression and physical interactions in humans. Proteins only expressed in restricted cell types, like recently evolved proteins, make few physical interactions. Most tissue-specific proteins do, however, bind to universally expressed proteins, and so can function by recruiting or modifying core cellular processes. Conversely, most 'housekeeping' proteins that are expressed in all cells also make highly tissue-specific protein interactions. These results suggest a model for the evolution of tissue-specific biology, and show that most, and possibly all, 'housekeeping' proteins actually have important tissue-specific molecular interactions.
蛋白质相互作用网络描述了蛋白质之间可能发生的一组物理关联。然而，在任何特定的细胞或组织中，只有一部分蛋白质会表达，因此只能发生一部分相互作用。整合相互作用和表达数据，我们在此分析人类蛋白质表达与物理相互作用之间的这种相互作用。仅在受限细胞类型中表达的蛋白质，如最近进化的蛋白质，很少发生物理相互作用。然而，大多数组织特异性蛋白质确实会与普遍表达的蛋白质结合，因此可以通过招募或修饰核心细胞过程来发挥作用。相反，在所有细胞中表达的大多数“管家”蛋白质也会形成高度组织特异性的蛋白质相互作用。这些结果提出了一个组织特异性生物学进化的模型，并表明大多数（可能是所有）“管家”蛋白质实际上都具有重要的组织特异性分子相互作用。
