Emory University School of Medicine, 101 Woodruff Circle, Atlanta, GA 30322, USA.
Am J Alzheimers Dis Other Demen. 2010 Mar;25(2):142-8. doi: 10.1177/1533317509333904. Epub 2009 Apr 9.
Disease-specific assessments are not currently available for patients with Parkinson's disease dementia (PDD). This study evaluated the criterion-related validity and test-retest reliability of the Alzheimer's Disease Assessment scale cognitive subscale (ADAS-cog) in terms of sensitivity for differentiation between mild and moderate severity impairment in PDD. Six other dementia rating scales and cognitive tests were also examined. A total of 113 patients with PDD or Alzheimer disease were recruited into this 4-week, multicenter study, segregated into 2 severity groups based on Mini-Mental State Examination (MMSE) score. Mean ADAS-cog scores showed a statistically significant separation between mild and moderate severity patients in both dementias (P < .001). For the ADAS-cog, test-retest Spearman correlation coefficients were significant for each dementia type and severity. This study demonstrated the criterion-related validity and test-retest reliability for ADAS-cog in patients with PDD and strong correlations with MMSE. This supports the validity of previous results obtained with these measures in studies of patients with PDD.
目前尚无针对帕金森病痴呆（PDD）患者的特定疾病评估工具。本研究评估了阿尔茨海默病评估量表认知分量表（ADAS-cog）在区分 PDD 轻度和中度严重程度损伤方面的效标关联效度和重测信度。还对其他六种痴呆评定量表和认知测验进行了评估。共有 113 例 PDD 或阿尔茨海默病患者入组了这项为期 4 周的多中心研究，根据简易精神状态检查（MMSE）评分将他们分为 2 个严重程度组。ADAS-cog 评分在两种痴呆症中均显示出轻度和中度严重程度患者之间的统计学显著差异（P <.001）。对于 ADAS-cog，每种痴呆类型和严重程度的重测 Spearman 相关系数均具有统计学意义。这项研究表明，ADAS-cog 在 PDD 患者中的效标关联效度和重测信度良好，与 MMSE 具有很强的相关性。这支持了以前在 PDD 患者研究中使用这些测量工具获得的结果的有效性。
