Tehran University of Medical Sciences, Oral Pathology, #2, Banafshe Alley, Karoon St., Tehran, Iran.
Oral Oncol. 2009 Jul;45(7):e41-4. doi: 10.1016/j.oraloncology.2008.12.007. Epub 2009 Apr 9.
Odontogenic keratocyst (OKC) has an aggressive clinical course and a high tendency toward recurrence, while orthokeratinized odontogenic cyst has different characteristics and does not show aggressive behavior. Bax and bcl-2 are two important anti-apoptotic and pro-apoptotic factors of the bcl-2 family. The different outcomes of theses two cysts could be related to these apopto-proteins. Twenty-eight cases of OKC and nine cases of orthokeratinized odontogenic cyst (OOC) were stained for bax and bcl-2 proteins. Immunoreactivity for bcl-2 was detected in the basal layer of OKCs, while OOCs were completely negative in the basal layer (P<0.001). Bcl-2 expression in the whole thickness of OKCs was also significantly higher than in OOCs (P<0.001). Bax expression did not show any statistically significant difference between the two cysts (P=0.077). The different behaviors of these cysts are compatible with their immunohistochemical view. Lower expression of bcl-2 in OOC ends in less aggressiveness and a lower tendency toward recurrence. Bax seems to play no significant role by itself; however, the bcl-2/bax ratio is probably a determinant factor for different outcomes.
牙源性角化囊肿（OKC）具有侵袭性的临床病程和高复发倾向，而正角化牙源性囊肿则具有不同的特征，并不表现出侵袭性行为。Bax 和 bcl-2 是 bcl-2 家族中两个重要的抗凋亡和促凋亡因子。这两种囊肿的不同结局可能与这些凋亡蛋白有关。对 28 例 OKC 和 9 例正角化牙源性囊肿（OOC）进行了 bax 和 bcl-2 蛋白染色。OKC 的基底层检测到 bcl-2 的免疫反应性，而 OOC 在基底层则完全呈阴性（P<0.001）。OKC 全层的 bcl-2 表达也明显高于 OOC（P<0.001）。Bax 的表达在两种囊肿之间没有统计学上的显著差异（P=0.077）。这些囊肿的不同行为与其免疫组织化学观点一致。OOC 中 bcl-2 的低表达导致侵袭性降低和复发倾向降低。Bax 本身似乎没有发挥重要作用；然而，bcl-2/bax 比值可能是决定不同结局的一个因素。
