Boucek P, Bartos V, Vanĕk I, Hýza Z, Skibová J
Institute for Clinical and Experimental Medicine, Prague, Czechslovakia.
Diabetologia. 1991 Aug;34 Suppl 1:S121-4.
We have evaluated the effect of successful pancreatic and kidney transplantation on autonomic neuropathy in nine Type 1 (insulin-dependent) diabetic subjects. Cardiovascular reflex tests were performed before and at 6-24 months after transplantation. A control group of ten Type 1 diabetic patients after kidney grafting only was examined at the same time periods. For base-line comparisons results of the tests in ten healthy subjects were used. Advanced autonomic neuropathy was present in both groups of transplant recipients and no significant changes in test results could be found at post-transplant evaluation. Lack of autonomic nerve function improvement was confirmed in seven patients of the pancreatic and kidney transplantation group who were examined again after 2-4 years. Irreversible structural autonomic nerve damage is probably present in uraemic pancreatic transplantation candidates.
我们评估了成功进行胰腺和肾脏移植对9名1型（胰岛素依赖型）糖尿病患者自主神经病变的影响。在移植前以及移植后6至24个月进行了心血管反射测试。同时对仅接受肾移植的10名1型糖尿病患者组成的对照组在相同时间段进行了检查。为进行基线比较，采用了10名健康受试者的测试结果。两组移植受者均存在严重的自主神经病变，移植后评估未发现测试结果有显著变化。在胰腺和肾脏移植组的7名患者中，2至4年后再次检查证实自主神经功能未改善。尿毒症胰腺移植候选者可能存在不可逆的结构性自主神经损伤。
