Safak Birol, Ciftci Ihsan Hakki, Ozdemir Mehmet, Kiyildi Nilay, Cetinkaya Zafer, Aktepe Orhan Cem, Altindis Mustafa, Asik Gulsah
Department of Microbiology, Faculty of Medicine, Kocatepe University, Afyonkarahisar, Turkey.
Phytother Res. 2009 Jul;23(7):955-7. doi: 10.1002/ptr.2690.
Eradication of Helicobacter pylori is an important objective in overcoming gastric diseases. Many regimens are currently available but none of them could achieve 100% success in eradication. Medicinal lichen is used in the treatment of gastric ulcer in local folk medicine in Anatolia (Turkey). The present study was performed to assess the in vitro effects of usnic acid from Usnea dasypoga against clinical isolates and standard H. pylori strains and their minimum inhibitory concentrations (MICs). A total of 38 strains was assayed for anti-H. pylori activity. The agar dilution method was used for the determination of usnic acid and clarithromycin resistance.Six (16.2%) clinical isolates were resistant to usnic acid and five (13.5%) were resistant to clarithromycin. Dual susceptibility to usnic acid and clarithromycin rate was detected as very high (97.3%). Usnic acid has a strong and dose-dependent activity against H. pylori strains. The synergism between usnic acid and clarithromycin may be effective in the treatment of H. pylori infection.
根除幽门螺杆菌是攻克胃部疾病的一项重要目标。目前有多种治疗方案，但尚无一种能实现100%的根除成功率。药用地衣在安纳托利亚（土耳其）当地民间医学中用于治疗胃溃疡。本研究旨在评估长松萝中松萝酸对临床分离株和标准幽门螺杆菌菌株的体外作用及其最低抑菌浓度（MIC）。共检测了38株菌株的抗幽门螺杆菌活性。采用琼脂稀释法测定松萝酸和克拉霉素耐药性。6株（16.2%）临床分离株对松萝酸耐药，5株（13.5%）对克拉霉素耐药。松萝酸和克拉霉素的双重敏感率非常高（97.3%）。松萝酸对幽门螺杆菌菌株具有强大的剂量依赖性活性。松萝酸与克拉霉素之间的协同作用可能对幽门螺杆菌感染的治疗有效。
