Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji, 133002, China.
Department of Pharmacy, Shandong Second Provincial General Hospital, Jinan, Shandong, China.
Mini Rev Med Chem. 2024;24(14):1368-1384. doi: 10.2174/0113895575277085231123165546.
Usnic acid has a variety of biological activities, and has been widely studied in the fields of antibacterial, immune stimulation, antiviral, antifungal, anti-inflammatory and antiparasitic. Based on this, usnic acid is used as the lead compound for structural modification. In order to enhance the biological activity and solubility of usnic acid, scholars have carried out a large number of structural modifications, and found some usnic acid derivatives to be of more potential research value. In this paper, the structural modification, biological activity and structure-activity relationship of usnic acid were reviewed to provide reference for the development of usnic acid derivatives.
松萝酸具有多种生物学活性，在抗菌、免疫刺激、抗病毒、抗真菌、抗炎和抗寄生虫等领域得到了广泛研究。基于此，松萝酸被用作结构修饰的先导化合物。为了提高松萝酸的生物活性和溶解度，学者们对其进行了大量的结构修饰，发现一些松萝酸衍生物具有更大的潜在研究价值。本文综述了松萝酸的结构修饰、生物活性和构效关系，为松萝酸衍生物的开发提供参考。
