Maayan M L, Volpert E M, From A
Endocrinology. 1981 May;108(5):1987-8. doi: 10.1210/endo-108-5-1987.
Excised mouse thyroids incubated in Ca++-free medium were stimulated to release increased amounts of stable thyroxine. This stimulation of thyroxine release by incubated thyroid tissue was not additive with TSH or (Bu)2cAMP. It was reversed by norepinephrine through an alpha adrenergic receptor, similar to TSH or (Bu)2cAMP stimulation. Depletion of Ca++ did not result, however, in an increase in the concentration of cAMP in incubated thyroid glands, suggesting that its locus of action was subsequent to TSH stimulation or cAMP production.
在无钙离子培养基中孵育的切除小鼠甲状腺被刺激释放出更多量的稳定甲状腺素。这种由孵育的甲状腺组织对甲状腺素释放的刺激与促甲状腺激素（TSH）或双丁酰环磷腺苷（Bu）2cAMP无叠加作用。去甲肾上腺素通过α肾上腺素能受体可逆转这种刺激，这与TSH或（Bu）2cAMP刺激相似。然而，钙离子的耗尽并未导致孵育的甲状腺中cAMP浓度升高，这表明其作用位点在TSH刺激或cAMP产生之后。
