锂对灌注系统中促甲状腺激素刺激的小鼠甲状腺释放甲状腺激素的抑制作用。

Inhibitory effect of lithium on the release of thyroid hormones from thyrotropin-stimulated mouse thyroids in a perifusion system.

作者信息

Mori M, Tajima K, Oda Y, Matsui I, Mashita K, Tarui S

机构信息

The Second Department of Internal Medicine, Osaka University Medical School, Japan.

出版信息

Endocrinology. 1989 Mar;124(3):1365-9. doi: 10.1210/endo-124-3-1365.

DOI:10.1210/endo-124-3-1365

PMID:2465138

Abstract

We studied the effect of lithium on the release of T3, T4, and cAMP from perifused mouse thyroids and on cAMP content in thyroid pieces. Lithium significantly inhibited T3 and T4 release from TSH-stimulated mouse thyroids. This inhibitory effect on thyroid hormone release was dependent on the concentration of lithium. Under continuous stimulation with TSH and 3-isobutyl-1-methylxanthine, both cAMP release and cAMP content were significantly decreased by lithium. In addition, we studied the effect of lithium on (Bu)2cAMP-stimulated thyroid hormone release. T3 and T4 release was stimulated by (Bu)2cAMP in a similar way to TSH. Lithium significantly inhibited (Bu)2 cAMP-stimulated T3 and T4 release from perifused mouse thyroids. These results suggest that lithium inhibits the action of TSH in the thyroid gland by both suppression of cAMP production and inhibition at a step beyond cAMP generation.

摘要

我们研究了锂对灌注的小鼠甲状腺释放T3、T4和cAMP以及对甲状腺组织中cAMP含量的影响。锂显著抑制促甲状腺激素（TSH）刺激的小鼠甲状腺释放T3和T4。这种对甲状腺激素释放的抑制作用取决于锂的浓度。在TSH和3-异丁基-1-甲基黄嘌呤持续刺激下，锂显著降低了cAMP的释放和cAMP含量。此外，我们研究了锂对双丁酰环磷腺苷（Bu）2cAMP刺激的甲状腺激素释放的影响。（Bu）2cAMP以与TSH相似的方式刺激T3和T4释放。锂显著抑制灌注的小鼠甲状腺中（Bu）2cAMP刺激的T3和T4释放。这些结果表明，锂通过抑制cAMP生成以及在cAMP生成之后的步骤发挥抑制作用，从而抑制TSH在甲状腺中的作用。