Devaraj Sridevi, Singh Uma, Jialal Ishwarlal
Laboratory for Atherosclerosis and Metabolic Research, University of California Davis Medical Center, Sacramento, California, and VA Medical Center, Mather, USA.
Curr Opin Lipidol. 2009 Jun;20(3):182-9. doi: 10.1097/MOL.0b013e32832ac03e.
Low-grade inflammation is characteristic of the metabolic syndrome (MetS). C-reactive protein (CRP), the best characterized biomarker of inflammation, is also an independent predictor of future cardiovascular events. The purpose of this review is to outline the role of inflammation and high sensitivity CRP in the MetS.
Emerging laboratory and epidemiological data now link inflammation and high sensitivity CRP to insulin resistance and adiposity and other features of MetS. Furthermore, in large prospective studies, increased high sensitivity CRP levels in MetS confer greater cardiovascular risk. CRP has been shown to impair insulin signaling and contributes to atherothrombosis.
Thus, although a high CRP level predisposes to increased cardiovascular risk in MetS, future investigation is warranted on the in-vivo role of CRP in mediating vascular effects and resulting in increased cardiovascular events in MetS patients.
低度炎症是代谢综合征（MetS）的特征。C反应蛋白（CRP）是最具特征的炎症生物标志物，也是未来心血管事件的独立预测因子。本综述的目的是概述炎症和高敏CRP在代谢综合征中的作用。
新出现的实验室和流行病学数据现在将炎症和高敏CRP与胰岛素抵抗、肥胖及代谢综合征的其他特征联系起来。此外，在大型前瞻性研究中，代谢综合征患者高敏CRP水平升高会带来更大的心血管风险。CRP已被证明会损害胰岛素信号传导并促成动脉粥样硬化血栓形成。
因此，虽然高CRP水平易使代谢综合征患者的心血管风险增加，但仍有必要进一步研究CRP在介导血管效应以及导致代谢综合征患者心血管事件增加方面的体内作用。
