胆囊肉瘤样癌的外科治疗
Surgical management of gallbladder sarcomatoid carcinoma.
作者信息
Liu Keng-Hao, Yeh Ta-Sen, Hwang Tsann-Long, Jan Yi-Yin, Chen Miin-Fu
机构信息
Department of General Surgery, Chang Gung Memorial Hospital, Chang Gung University, Kwei-Shan, Taoyuan, Taiwan, China.
出版信息
World J Gastroenterol. 2009 Apr 21;15(15):1876-9. doi: 10.3748/wjg.15.1876.
AIM
To study the behavior as well as optimal treatment of gallbladder sarcomatoid carcinoma, we reviewed the results of treatment of gallbladder sarcomatoid carcinoma from Chang Gung Memorial Hospital.
METHODS
From 1987 to 2005, six patients were diagnosed with gallbladder sarcomatoid carcinoma and treated at our institution. Tumor staging was based on 2002 revised tumor-node-metastasis (TNM) staging for gall bladder cancer from the American Joint Committee on Cancer. The clinical presentation, laboratory data and preoperative workup were reviewed retrospectively.
RESULTS
Five patients were female and one was male. The age ranged from 51 to 66 years (median, 58 years). Surgical procedures included three curative resections, two palliative resections and one biopsy. There were two surgical complications (33.3%) and one case of surgical mortality (16.7%). The follow-up time ranged from 30 d to 5 mo. The median survival was 2.5 mo. The prognosis was extremely poor, even after curative resection and postoperative chemotherapy.
CONCLUSION
The prognosis of gallbladder sarcomatoid carcinoma was not dependent on TNM stage and was always dismal. The clinicopathological features were different from those of gall bladder cancer.
目的
为研究胆囊肉瘤样癌的行为及最佳治疗方法，我们回顾了长庚纪念医院胆囊肉瘤样癌的治疗结果。
方法
1987年至2005年，6例胆囊肉瘤样癌患者在我院确诊并接受治疗。肿瘤分期基于美国癌症联合委员会2002年修订的胆囊癌肿瘤-淋巴结-转移（TNM）分期。回顾性分析临床表现、实验室数据及术前检查结果。
结果
5例女性，1例男性。年龄51至66岁（中位年龄58岁）。手术方式包括3例根治性切除、2例姑息性切除和1例活检。有2例手术并发症（33.3%）和1例手术死亡（16.7%）。随访时间30天至5个月。中位生存期为2.5个月。即使经过根治性切除和术后化疗，预后仍然极差。
结论
胆囊肉瘤样癌的预后不依赖于TNM分期，且总是很差。其临床病理特征与胆囊癌不同。
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