• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

发热性中性粒细胞减少症的变化面貌——从单一疗法到霉菌感染再到黏膜炎。黏膜炎：从发热性中性粒细胞减少症到发热性黏膜炎。

The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Mucositis: from febrile neutropenia to febrile mucositis.

作者信息

Blijlevens Nicole M A, Logan Richard M, Netea Mihai G

机构信息

Department of Haematology, Radboud University Medical Center, PO Box 9101, NL-6500 HB Nijmegen, The Netherlands.

出版信息

J Antimicrob Chemother. 2009 May;63 Suppl 1:i36-40. doi: 10.1093/jac/dkp081.

DOI:10.1093/jac/dkp081
PMID:19372181
Abstract

The treatment of patients with cancer is often accompanied by life-threatening complications caused by chemotherapy and radiotherapy. They are known to result from neutropenia, but damage to the mucosal barrier as well as the humoral and cellular immune defences play a significant role in various infectious complications and aggravate diverse inflammatory processes. The article describes the journey from febrile neutropenia to febrile mucositis in patients treated with immunocompromising therapy.

摘要

癌症患者的治疗常常伴随着化疗和放疗引发的危及生命的并发症。已知这些并发症是由中性粒细胞减少引起的，但黏膜屏障以及体液和细胞免疫防御的损伤在各种感染性并发症中起着重要作用，并加剧了各种炎症过程。本文描述了接受免疫抑制治疗的患者从发热性中性粒细胞减少到发热性黏膜炎的病程。

相似文献

1
The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Mucositis: from febrile neutropenia to febrile mucositis.发热性中性粒细胞减少症的变化面貌——从单一疗法到霉菌感染再到黏膜炎。黏膜炎：从发热性中性粒细胞减少症到发热性黏膜炎。
J Antimicrob Chemother. 2009 May;63 Suppl 1:i36-40. doi: 10.1093/jac/dkp081.
2
The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Summary and comments.发热性中性粒细胞减少症的变化面貌——从单一疗法到霉菌感染再到黏膜炎。总结与评论。
J Antimicrob Chemother. 2009 May;63 Suppl 1:i41-3. doi: 10.1093/jac/dkp082.
3
The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Why empirical therapy?发热性中性粒细胞减少症的变化面貌——从单一疗法到霉菌感染再到粘膜炎。为何采用经验性治疗？
J Antimicrob Chemother. 2009 May;63 Suppl 1:i14-5. doi: 10.1093/jac/dkp075.
4
The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Where do we go from here?发热性中性粒细胞减少症的变化面貌——从单一疗法到霉菌感染再到粘膜炎。我们从这里何去何从？
J Antimicrob Chemother. 2009 May;63 Suppl 1:i16-7. doi: 10.1093/jac/dkp076.
5
The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Fever and neutropenia: the early years.发热性中性粒细胞减少症的变化面貌——从单一疗法到霉菌感染再到黏膜炎。发热与中性粒细胞减少症：早期情况。
J Antimicrob Chemother. 2009 May;63 Suppl 1:i3-13. doi: 10.1093/jac/dkp074.
6
The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Why monotherapy?
J Antimicrob Chemother. 2009 May;63 Suppl 1:i18-20. doi: 10.1093/jac/dkp077.
7
The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Moulds: diagnosis and treatment.
J Antimicrob Chemother. 2009 May;63 Suppl 1:i31-5. doi: 10.1093/jac/dkp080.
8
Empiric versus preemptive therapy in the management of febrile neutropenia in the patient being treated for hematologic malignancy.经验性治疗与抢先治疗在血液系统恶性肿瘤患者发热性中性粒细胞减少症管理中的应用
Transpl Infect Dis. 2006 Mar;8(1):1-2. doi: 10.1111/j.1399-3062.2006.00123.x.
9
The changing face of febrile neutropenia-from monotherapy to moulds to mucositis. Prevention of mould infections.发热性中性粒细胞减少症的变化面貌——从单一疗法到霉菌感染再到黏膜炎。霉菌感染的预防。
J Antimicrob Chemother. 2009 May;63 Suppl 1:i27-30. doi: 10.1093/jac/dkp084.
10
Herpes simplex infection as possible etiology for febrile neutropenia and mucositis in patients treated for hematological malignancies.单纯疱疹感染可能是血液系统恶性肿瘤患者发热性中性粒细胞减少症和粘膜炎的病因。
Acta Med Austriaca. 1998;25(2):57-60.

引用本文的文献

1
The role of compounded mouthwash with or without acyclovir in managing chemotherapy-induced oral mucositis in cancer patients: a randomized controlled trial.含或不含阿昔洛韦的复方漱口水在癌症患者化疗所致口腔黏膜炎管理中的作用：一项随机对照试验
BMC Oral Health. 2025 Jun 21;25(1):953. doi: 10.1186/s12903-025-06324-4.
2
Clinical Risk Factors for High-Dose Methotrexate-Induced Oral Mucositis Following Individualized Dosing.个体化剂量后大剂量甲氨蝶呤致口腔黏膜炎的临床危险因素。
Cancer Med. 2024 Nov;13(21):e70351. doi: 10.1002/cam4.70351.
3
Why do patients with cancer die?
为什么癌症患者会死亡？
Nat Rev Cancer. 2024 Aug;24(8):578-589. doi: 10.1038/s41568-024-00708-4. Epub 2024 Jun 19.
4
The Role of the Innate Immune Response in Oral Mucositis Pathogenesis.固有免疫应答在口腔黏膜炎发病机制中的作用。
Int J Mol Sci. 2023 Nov 14;24(22):16314. doi: 10.3390/ijms242216314.
5
The Microbiome and Its Impact on Allogeneic Hematopoietic Cell Transplantation.微生物组及其对异基因造血细胞移植的影响。
Cancer J. 2023;29(2):75-83. doi: 10.1097/PPO.0000000000000645.
6
Application of big data analyses to compare the impact of oral and gastrointestinal mucositis on risks and outcomes of febrile neutropenia and septicemia among patients hospitalized for the treatment of leukemia or multiple myeloma.应用大数据分析比较口腔和胃肠道黏膜炎对因白血病或多发性骨髓瘤住院治疗患者发热性中性粒细胞减少症和败血症风险及结局的影响。
Support Care Cancer. 2023 Mar 4;31(3):199. doi: 10.1007/s00520-023-07654-1.
7
Life-threatening oral mucositis following chemotherapy in a pediatric patient.一名儿科患者化疗后出现危及生命的口腔黏膜炎。
Clin Case Rep. 2021 Jun 10;9(6):e04356. doi: 10.1002/ccr3.4356. eCollection 2021 Jun.
8
Translational model of melphalan-induced gut toxicity reveals drug-host-microbe interactions that drive tissue injury and fever.美法仑诱导的肠道毒性转化模型揭示了药物-宿主-微生物相互作用，这些相互作用导致组织损伤和发热。
Cancer Chemother Pharmacol. 2021 Aug;88(2):173-188. doi: 10.1007/s00280-021-04273-7. Epub 2021 Apr 20.
9
Anakinra: efficacy in the management of fever during neutropenia and mucositis in autologous stem cell transplantation (AFFECT-2)-study protocol for a multicenter randomized double-blind placebo-controlled trial.阿那白滞素在自体干细胞移植中中性粒细胞减少和黏膜炎相关发热的疗效（AFFECT-2）：一项多中心随机双盲安慰剂对照试验的研究方案。
Trials. 2020 Nov 23;21(1):948. doi: 10.1186/s13063-020-04847-5.
10
Effect of vitamin A on intestinal mucosal injury in pediatric patients receiving hematopoietic stem cell transplantation and chemotherapy: a quasai-randomized trial.维生素A对接受造血干细胞移植和化疗的儿科患者肠道黏膜损伤的影响：一项半随机试验。
BMC Res Notes. 2020 Oct 2;13(1):464. doi: 10.1186/s13104-020-05307-8.