Koukourakis Michael I, Kambouromiti Georgia, Pitsiava Dimitra, Tsousou Pelagia, Tsiarkatsi Maria, Kartalis George
Department of Radiotherapy/Oncology, University Hospital of Alexandroupolis, Democritus University of Thrace, Alexandroupolis, Greece.
Inflammation. 2009 Jun;32(3):169-75. doi: 10.1007/s10753-009-9116-4.
High levels of CRP relate with advanced disease and poor prognosis of cancer patients. CRP serum levels were measured in 684 cancer patients who had undergone complete surgery or inoperable patients. Patients with inoperable tumors had significantly higher CRP levels (1.21 +/- 2.2 vs. 0.40 +/- 0.4 mg/dL; p < 0.0001). No association with gender, diabetes, autoimmune disease, thyroid disease or allergy was noted. Significantly higher CRP levels were noted in operated patients with hypertension (0.55 +/- 0.5 vs. 0.35 +/- 0.4; p = 0.001), coronary disease (0.73 +/- 0.8 vs. 0.39 +/- 0.4; p = 0.01) and obesity (0.51 +/- 0.5 vs. 0.37 +/- 0.4; p = 0.04). On the contrary, analysis in the group of inoperable patients showed that hypertensive patients had significantly lower CRP levels (0.64 +/- 1.0 vs. 1.36 +/- 2.4; p = 0.008). Although the tumor itself is the main factor defining increased CRP levels in cancer patients, hypertension, coronary disease and obesity are also linked with high CRP levels. Anti-hypertensive drugs appear as potent suppressors of the tumor-induced CRP production.
高浓度的C反应蛋白（CRP）与癌症患者的疾病进展及不良预后相关。对684例接受了根治性手术的癌症患者或无法手术的患者测定了血清CRP水平。无法手术的肿瘤患者的CRP水平显著更高（1.21±2.2 vs. 0.40±0.4mg/dL；p<0.0001）。未发现与性别、糖尿病、自身免疫性疾病、甲状腺疾病或过敏有关联。接受手术的高血压患者（0.55±0.5 vs. 0.35±0.4；p = 0.001）、冠心病患者（0.73±0.8 vs. 0.39±0.4；p = 0.01）和肥胖患者（0.51±0.5 vs. 0.37±0.4；p = 0.04）的CRP水平显著更高。相反，对无法手术患者组的分析显示，高血压患者的CRP水平显著更低（0.64±1.0 vs. 1.36±2.4；p = 0.008）。虽然肿瘤本身是决定癌症患者CRP水平升高的主要因素，但高血压、冠心病和肥胖也与高CRP水平有关。抗高血压药物似乎是肿瘤诱导的CRP产生的有效抑制剂。
