Lohr Jens, Knoechel Birgit, Caretto David, Abbas Abul K
Department of Pathology, University of California, School of Medicine, San Francisco, CA 94143, USA.
Microbes Infect. 2009 Apr;11(5):589-93. doi: 10.1016/j.micinf.2009.04.012. Epub 2009 Apr 17.
Transfer of antigen-specific T cells into antigen-expressing lymphopenic recipients leads to the sequential generation of Th1 and Th17 effector and protective CD25(+)FoxP3(+) regulatory cells in the periphery with surprisingly different kinetics. Such an experimental model is potentially valuable for defining the stimuli that regulate lineage decision and plasticity of various T cell effectors and peripheral regulatory T cells. Our studies have shown that IL-17 production occurs rapidly and declines within the first week with the appearance of IFN-gamma producing T cells. Regulatory T cells appear during the recovery phase of the disease. The factors that mediate this complex differentiation originating from a starting naïve T cell population remain to be defined.
将抗原特异性T细胞转移至表达抗原的淋巴细胞减少的受体中，会导致外周依次产生Th1和Th17效应细胞以及具有保护作用的CD25(+)FoxP3(+)调节性细胞，其动力学变化惊人地不同。这样的实验模型对于确定调节各种T细胞效应器和外周调节性T细胞谱系决定及可塑性的刺激因素可能具有重要价值。我们的研究表明，IL-17的产生迅速，在第一周内随着产生IFN-γ的T细胞的出现而下降。调节性T细胞在疾病的恢复阶段出现。介导从初始T细胞群体开始的这种复杂分化的因素仍有待确定。
