Bavdekar A, Chaudhari M, Bhave S, Pandit A
Department of Pediatrics, K.E.M. Hospital, Pune.
Indian J Pediatr. 1991 May-Jun;58(3):335-9. doi: 10.1007/BF02754962.
The study covers 78 children with typhoid fever who were hospitalized in April & May 1990. Serious complications were present in 32% (toxemia 22%, ileus 25% and myocarditis 8%). Blood cultures were positive in 30 of 49 tested. Others were diagnosed by positive Widal test. In vitro cultures of S. typhi were resistant to chloramphenicol (90%), ampicillin (93%) and co-trimoxazole (97%). However all were highly sensitive to ciprofloxacin and moderately sensitive to cephalexin and gentamycin. Ciprofloxacin alone or in combination was given in 73 of the 78 children and found to be remarkably effective in controlling the disease and preventing relapse. No serious side effects were noted. The cohort is being followed up for possible long term adverse effects.
该研究涵盖了1990年4月和5月住院的78名伤寒患儿。32%的患儿出现严重并发症（毒血症22%、肠梗阻25%、心肌炎8%）。49例接受检测的患儿中，30例血培养呈阳性。其他患儿通过肥达试验阳性确诊。伤寒杆菌的体外培养对氯霉素（90%）、氨苄西林（93%）和复方新诺明（97%）耐药。然而，所有菌株对环丙沙星高度敏感，对头孢氨苄和庆大霉素中度敏感。78名患儿中的73名单独或联合使用了环丙沙星，发现其在控制疾病和预防复发方面非常有效。未观察到严重副作用。该队列正在接受随访，以了解可能的长期不良反应。
