van Dusseldorp M, Smits P, Lenders J W, Thien T, Katan M B
Department of Medicine, University of Nijmegen, The Netherlands.
Hypertension. 1991 Nov;18(5):607-13. doi: 10.1161/01.hyp.18.5.607.
The question of whether long-term elimination of coffee from the diet lowers blood pressure has not been settled. Consumption of Scandinavian-style "boiled coffee" is associated with coronary heart disease. However, little is known about the effect of brewing method on the blood pressure-raising potential of coffee. We have studied the effects on blood pressure and heart rate of total elimination of coffee and tea in comparison with drinking boiled coffee consumed as such, or boiled coffee consumed after filtration through paper filter. Thirty-one women and 33 men first consumed 6 cups/day of boiled and filtered coffee for 17 days. Then they were randomly divided into three groups, which for the next 79 days received either unfiltered boiled coffee (caffeine content 860 mg/l), boiled-and-filtered coffee (887 mg caffeine/l), or no coffee, the latter being replaced by fruit juice and mineral water. Total elimination of coffee did not significantly affect blood pressure or heart rate relative to boiled-and-filtered coffee. In subjects who drank boiled coffee, mean ambulant systolic blood pressure rose significantly relative to those who consumed boiled-and-filtered coffee (mean difference +/- SEM, 3.1 +/- 1.1 mm Hg, p = 0.006). This response showed a tendency to be stronger for women (4.5 +/- 1.8 mm Hg) than for men (1.7 +/- 1.2 mm Hg). We conclude that elimination of filtered coffee has no substantial long-term effect on blood pressure, but consumption of unfiltered boiled coffee may cause a slight but significant rise in systolic blood pressure.
从饮食中长期戒除咖啡是否能降低血压这一问题尚无定论。饮用斯堪的纳维亚风格的“煮咖啡”与冠心病有关。然而,关于冲泡方法对咖啡升高血压潜力的影响却知之甚少。我们研究了完全戒除咖啡和茶对血压及心率的影响,并与直接饮用煮咖啡或用滤纸过滤后饮用煮咖啡的情况进行了比较。31名女性和33名男性首先连续17天每天饮用6杯煮咖啡和过滤咖啡。然后他们被随机分为三组,在接下来的79天里,一组饮用未过滤的煮咖啡(咖啡因含量860毫克/升),一组饮用过滤后的煮咖啡(咖啡因含量887毫克/升),另一组不喝咖啡,用果汁和矿泉水替代。与饮用过滤后的煮咖啡相比,完全戒除咖啡对血压和心率没有显著影响。在饮用煮咖啡的受试者中,平均动态收缩压相对于饮用过滤后煮咖啡的受试者显著升高(平均差值±标准误,3.1±1.1毫米汞柱,p = 0.006)。这种反应在女性(4.5±1.8毫米汞柱)中比在男性(1.7±1.2毫米汞柱)中更强。我们得出结论,戒除过滤咖啡对血压没有实质性的长期影响,但饮用未过滤的煮咖啡可能会导致收缩压轻微但显著升高。