维生素D与接受家庭健康服务的老年人的认知功能有关。
Vitamin D is associated with cognitive function in elders receiving home health services.
作者信息
Buell Jennifer S, Scott Tammy M, Dawson-Hughes Bess, Dallal Gerard E, Rosenberg Irwin H, Folstein Marshal F, Tucker Katherine L
机构信息
Jean Mayer USDA Human Nutrition Research Center on Aging, Tufts University, 711 Washington Street, Boston, MA 02111, USA.
出版信息
J Gerontol A Biol Sci Med Sci. 2009 Aug;64(8):888-95. doi: 10.1093/gerona/glp032. Epub 2009 Apr 17.
BACKGROUND
The objective of this study was to examine the association between 25-hydroxyvitamin D, 25(OH)D, and cognitive function.
METHODS
A cross-sectional investigation of 25(OH)D and cognition was completed in 377 black and 703 non-black (mainly Caucasian) elders (65-99 years) participating in the nutrition and memory in elders study. Participants underwent a comprehensive neuropsychological battery, and 25(OH)D concentrations were obtained.
RESULTS
More than 65% of elders had suboptimal 25(OH)D concentrations (< or =20 ng/mL or < or =50 nmol/L). Approximately 18% were deficient in 25(OH)D (<10 ng/mL or <25 nmol/L). After adjusting for age, sex, race, body mass index, education, center, kidney function, seasonality, physical activity, and alcohol use, 25(OH)D was associated with better performance on trails A (beta = -0.49, p < .03), trails B (beta = -0.73, p < .02), digit symbol (beta = 0.19, p < .001), matrix reasoning (beta = 0.04, p < .02), and block design (beta = 0.07, p < .04) tests. Associations remained after adjustment for homocysteine, apoE4 allele, plasma B vitamins, and multivitamin use (y/n). 25(OH)D concentrations >20 ng/mL were associated with better performance on tests of executive function, including trails A (80.5 vs 95, p < .05), trails B (205s vs 226s, p < .05), matrix reasoning (7.8 vs 7.0, p = .03), and digit symbol (31.5 vs 37, p < .01). There were no associations between 25(OH)D and memory tests. Factor analysis yielded factors for memory, executive function, and attention/processing speed. After adjustment, 25(OH)D was associated with the executive function (beta = 0.01, p < 0.01) and attention/processing speed factors (beta = 0.01, p = .03), but not the memory factor (beta = -0.001, p = 0.65).
CONCLUSIONS
25(OH)D was positively associated with cognitive performance, particularly with measures of executive function in this elderly population.
背景
本研究的目的是检验25-羟维生素D[25(OH)D]与认知功能之间的关联。
方法
对参与老年人营养与记忆研究的377名黑人及703名非黑人（主要为白种人）老年人（65 - 99岁）进行了一项关于25(OH)D与认知的横断面调查。参与者接受了一套全面的神经心理学测试，并测定了25(OH)D浓度。
结果
超过65%的老年人25(OH)D浓度未达最佳水平（≤20 ng/mL或≤50 nmol/L）。约18%的老年人25(OH)D缺乏（<10 ng/mL或<25 nmol/L）。在调整年龄、性别、种族、体重指数、教育程度、研究中心、肾功能、季节因素、身体活动及饮酒情况后，25(OH)D与A线试验（β = -0.49，p < 0.03）、B线试验（β = -0.73，p < 0.02）、数字符号试验（β = 0.19，p < 0.001）、矩阵推理试验（β = 0.04，p < 0.02）及积木图案试验（β = 0.07，p < 0.04）的较好表现相关。在校正同型半胱氨酸、载脂蛋白E4等位基因、血浆B族维生素及复合维生素使用情况（是/否）后，关联依然存在。25(OH)D浓度>20 ng/mL与执行功能测试的较好表现相关，包括A线试验（80.5对95，p < 0.05）、B线试验（205秒对226秒，p < 0.05）、矩阵推理试验（7.8对7.0，p = 0.03）及数字符号试验（31.5对37，p < 0.01）。25(OH)D与记忆测试之间无关联。因子分析得出了记忆、执行功能及注意力/处理速度的因子。调整后，25(OH)D与执行功能因子（β = 0.01，p < 0.01）及注意力/处理速度因子（β = 0.01，p = 0.03）相关，但与记忆因子无关（β = -0.001，p = 0.65）。
结论
在该老年人群中，25(OH)D与认知表现呈正相关，尤其是与执行功能指标相关。
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