重组γ干扰素和肿瘤坏死因子对人单核吞噬细胞与粗球孢子菌体外相互作用的影响。
Effects of recombinant gamma interferon and tumor necrosis factor on in vitro interactions of human mononuclear phagocytes with Coccidioides immitis.
作者信息
Beaman L
机构信息
Medical Microbiology and Immunology, University of California School of Medicine, Davis 95616.
出版信息
Infect Immun. 1991 Nov;59(11):4227-9. doi: 10.1128/iai.59.11.4227-4229.1991.
Abstract
Human peripheral blood monocytes readily phagocytized Coccidioides immitis endospores (2 to 5 microns) in vitro. Within 24 to 30 h at 37 degrees C, the phagocytized endospores started developing into immature spherules. However, when the monocytes were incubated with recombinant human gamma interferon (rIFN-gamma) or recombinant human tumor necrosis factor alpha (rTNF-alpha) and then infected, fewer endospores developed into spherules. Treatment with rIFN-gamma or rTNF-alpha activated the fungicidal capabilities of the monocytes as evidenced by the significant reduction in CFU that could be recovered from rIFN-gamma- or rTNF-alpha-activated monocytes compared with nontreated controls.
摘要
人外周血单核细胞在体外能轻易吞噬粗球孢子菌内孢子（2至5微米）。在37摄氏度下24至30小时内，被吞噬的内孢子开始发育成未成熟的球形体。然而，当单核细胞与重组人γ干扰素（rIFN-γ）或重组人肿瘤坏死因子α（rTNF-α）一起孵育然后感染时，发育成球形体的内孢子较少。与未处理的对照相比，用rIFN-γ或rTNF-α处理激活了单核细胞的杀真菌能力，这可从rIFN-γ或rTNF-α激活的单核细胞中回收的菌落形成单位（CFU）显著减少得到证明。
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