D'Mello N P, Jazwinski S M
Department of Biochemistry and Molecular Biology, Louisiana State University Medical Center, New Orleans 70112.
J Bacteriol. 1991 Nov;173(21):6709-13. doi: 10.1128/jb.173.21.6709-6713.1991.
It has been proposed that a decrease in the length of telomeres with the successive rounds of DNA replication that accompany mitotic division could play a causal role in the aging process. To investigate this possibility, telomeres from cells of the budding yeast Saccharomyces cerevisiae that varied in replicative age were examined. No change in the lengths of the telomeres was observed in cells that had completed up to 83% of the mean life span. We conclude that the length of the telomeres is not a contributing factor in the natural aging process in individual yeast cells.
有人提出，随着有丝分裂伴随的DNA复制连续轮次，端粒长度的减少可能在衰老过程中起因果作用。为了研究这种可能性，对不同复制年龄的芽殖酵母酿酒酵母细胞的端粒进行了检测。在完成平均寿命83%以内的细胞中，未观察到端粒长度的变化。我们得出结论，端粒长度不是单个酵母细胞自然衰老过程中的一个促成因素。
