Chowdhury Tahseen A, Boucher Barbara J, Hitman Graham A
Prim Care Diabetes. 2009 May;3(2):115-6. doi: 10.1016/j.pcd.2009.03.004. Epub 2009 Apr 23.
Prevention, or at least delay in onset of type 2 diabetes is possible by intensive lifestyle intervention. This is costly and labour intensive, and alternative methods of preventing diabetes have been sought. Vitamin D has important physiological effects aside from its effects on bone metabolism, including an important role in glucose homeostasis, insulin release and response. Observational data strongly support the role of vitamin D deficiency in the pathogenesis of type 2 diabetes. The time is ripe for a well conducted randomised controlled trial of vitamin D in high risk individuals to test the hypothesis that vitamin D delays the onset of type 2 diabetes.
通过强化生活方式干预预防2型糖尿病，或者至少延缓其发病是有可能的。这成本高昂且劳动强度大，因此人们一直在寻找预防糖尿病的替代方法。维生素D除了对骨代谢有影响外，还具有重要的生理作用，包括在葡萄糖稳态、胰岛素释放和反应中起重要作用。观察数据有力地支持了维生素D缺乏在2型糖尿病发病机制中的作用。开展一项针对高危个体的维生素D随机对照试验，以检验维生素D可延缓2型糖尿病发病这一假设的时机已经成熟。
