Srimani Soumi, Saha Indranil, Chaudhuri Debnath
Department of Biochemistry and Nutrition, All India Institute of Hygiene and Public Health, Kolkata, West Bengal, India.
Department of Community Medicine, IQ City Medical College and Narayana Hrudayalaya Hospital, Durgapur, West Bengal, India.
PLoS One. 2017 Nov 30;12(11):e0188331. doi: 10.1371/journal.pone.0188331. eCollection 2017.
Prevalence of metabolic syndrome (MS) and vitamin D deficiency was reported among postmenopausal women (PMW) in India. However, no report is available regarding the association of MS and 25-hydroxyvitamin D [25(OH)D] among PMW in India. This study aimed to find out the prevalence of MS and 25(OH)D status as well as their association among rural PMW of West Bengal, India.
This cross-sectional study was conducted among 222 randomly selected rural PMW in Singur Block, West Bengal, India. Serum 25(OH)D, Blood pressure (BP), waist circumference (WC), fasting blood glucose (FBG), triglycerides (TG) and high density lipoprotein cholesterol (HDL-C) were measured using standard procedures. MS was defined as per International Diabetes Federation, 2005 (for Asian-Indians) criteria. Statistical tests were done using SPSS software.
Prevalence of metabolic syndrome was 46%. 51% and 19% PMW were vitamin D insufficient and deficient, respectively. 22% and 53% women having MS were vitamin D insufficient and deficient, respectively. Among the PMW, 21% and 47% with WC≥80cm; 22% and 62% with FBG≥110mg/dl; 21% and 54% with TG≥150mg/dl; 23% and 51% with HDL-C<50mg/dl, 15% and 55% with BP≥130/85mm of Hg were vitamin D insufficient and deficient, respectively. Significant statistical association between FBG and 25(OH)D status existed (p = 0.01). Significant positive correlation between WC and 25(OH)D level (p = 0.004) and significant negative correlation between FBG and 25(OH)D level observed (p = 0.02). WC was the only statistically significant predictor of the dependent variable. Odds of non-sufficient 25(OH)D level increased with decrease in WC.
High prevalence of MS as well as vitamin D insufficiency and deficiency existed among PMW of Singur block, West Bengal, India. 25(OH)D had significant inverse and direct relationship with FBG and WC. Low 25(OH)D may be one of the potential risk factors for developing MS in PMW or vice-versa.
据报道，印度绝经后女性（PMW）中代谢综合征（MS）和维生素D缺乏症的患病率情况。然而，关于印度PMW中MS与25-羟基维生素D [25(OH)D]之间的关联尚无相关报告。本研究旨在了解印度西孟加拉邦农村PMW中MS的患病率、25(OH)D状况及其两者之间的关联。
本横断面研究在印度西孟加拉邦辛古尔街区随机选取的222名农村PMW中进行。采用标准程序测量血清25(OH)D、血压（BP）、腰围（WC）、空腹血糖（FBG）、甘油三酯（TG）和高密度脂蛋白胆固醇（HDL-C）。MS根据国际糖尿病联盟2005年（针对亚洲印度人）标准进行定义。使用SPSS软件进行统计检验。
代谢综合征的患病率为46%。分别有51%和19%的PMW维生素D不足和缺乏。患有MS的女性中分别有22%和53%维生素D不足和缺乏。在PMW中，腰围≥80cm的人群中分别有21%和47%；空腹血糖≥110mg/dl的人群中分别有22%和62%；甘油三酯≥150mg/dl的人群中分别有21%和54%；高密度脂蛋白胆固醇<50mg/dl的人群中分别有23%和51%；血压≥130/85mmHg的人群中分别有15%和55%维生素D不足和缺乏。空腹血糖与25(OH)D状况之间存在显著的统计学关联（p = 0.01）。腰围与25(OH)D水平之间存在显著正相关（p = 0.004），空腹血糖与25(OH)D水平之间存在显著负相关（p = 0.02）。腰围是因变量唯一具有统计学意义的预测因素。25(OH)D水平不足的几率随腰围减小而增加。
印度西孟加拉邦辛古尔街区的PMW中MS以及维生素D不足和缺乏的患病率较高。25(OH)D与空腹血糖和腰围之间存在显著的负相关和正相关。低水平的25(OH)D可能是PMW发生MS的潜在危险因素之一，反之亦然。
