Department of Epidemiology, Epidemiology and Surveillance Research, American Cancer Society, National Home Office, 250 Williams Street NW, Atlanta, GA 30303, USA.
Cancer Causes Control. 2009 Oct;20(8):1261-9. doi: 10.1007/s10552-009-9339-6. Epub 2009 Apr 25.
A family history of pancreatic cancer is associated with increased risk of pancreatic cancer, but uncertainty remains about the magnitude of this association, whether it varies by age or smoking and whether a family history of other cancers may also be associated with increased risk. We examined family history of 14 cancers and pancreatic cancer mortality among ~1.1 million men and women in Cancer Prevention Study-II (CPS-II). CPS-II participants completed a questionnaire at enrollment in 1982. During follow-up through 2006, there were 7,306 pancreatic cancer deaths. A family history of pancreatic cancer in a parent or sibling was associated with pancreatic cancer mortality [multivariable adjusted rate ratio (RR) = 1.66, 95% confidence interval (CI) 1.43-1.94]. This association was stronger among participants aged under 60 (RR = 2.89, 95% CI 1.67-5.02) than among participants aged 60 or older (RR = 1.61, 95% CI 1.37-1.88). Weaker associations were observed for family history of stomach cancer (RR = 1.23, 95% CI 1.11-1.37), liver cancer (RR = 1.25, 95% CI 1.10-1.43), and colorectal cancer (RR = 1.12, 95% CI 1.01-1.23). Results from this large prospective study indicate family history of pancreatic cancer is associated with a moderate increase in risk of pancreatic cancer, and also identify associations with the family history of certain other cancers which may be useful in generating hypotheses about shared risk factors.
家族胰腺癌史与胰腺癌风险增加相关，但这种关联的程度、是否因年龄或吸烟而有所不同，以及家族其他癌症史是否也与风险增加相关，仍存在不确定性。我们在癌症预防研究 II（CPS-II）中检查了约 110 万男性和女性的 14 种癌症家族史和胰腺癌死亡率。CPS-II 参与者在 1982 年入组时完成了一份问卷。在 2006 年之前的随访期间，有 7306 例胰腺癌死亡。父母或兄弟姐妹中有胰腺癌家族史与胰腺癌死亡率相关[多变量校正后的比率（RR）=1.66，95%置信区间（CI）1.43-1.94]。在年龄小于 60 岁的参与者中，这种关联更强（RR=2.89，95%CI 1.67-5.02），而在 60 岁或以上的参与者中，这种关联较弱（RR=1.61，95%CI 1.37-1.88）。对于胃癌（RR=1.23，95%CI 1.11-1.37）、肝癌（RR=1.25，95%CI 1.10-1.43）和结直肠癌（RR=1.12，95%CI 1.01-1.23）的家族史，观察到的关联较弱。这项大型前瞻性研究的结果表明，家族胰腺癌史与胰腺癌风险的中度增加相关，并且还确定了与某些其他癌症家族史的关联，这可能有助于提出关于共同风险因素的假设。
