手性磷酸催化的对映选择性氮杂-Darzens反应
Enantioselective aza-Darzens reaction catalyzed by a chiral phosphoric acid.
作者信息
Akiyama Takahiko, Suzuki Tohru, Mori Keiji
机构信息
Department of Chemistry, Gakushuin University, 1-5-1 Mejiro, Toshima-ku, Tokyo 171-8588, Japan.
出版信息
Org Lett. 2009 Jun 4;11(11):2445-7. doi: 10.1021/ol900674t.
PMID:19397337
Abstract
Aza-Darzens reaction of ethyl diazoacetate with aldimines, derived from phenyl glyoxal, furnished cis-aziridine carboxylates with excellent enantioselectivities by means of a chiral phosphoric acid.
摘要
重氮乙酸乙酯与源自苯乙二醛的醛亚胺发生的氮杂-Darzens反应，通过手性磷酸得到了具有优异对映选择性的顺式氮丙啶羧酸酯。
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