吖啶橙和SYTO 16用于小鼠腹膜组织体内成像的评估。
Assessment of acridine orange and SYTO 16 for in vivo imaging of the peritoneal tissues in mice.
作者信息
Udovich J A, Besselsen D G, Gmitro A F
机构信息
College of Optical Sciences, University of Arizona, Tucson, Arizona, USA.
出版信息
J Microsc. 2009 May;234(2):124-9. doi: 10.1111/j.1365-2818.2009.03153.x.
Abstract
The effect of peritoneal injection of acridine orange and SYTO 16 in mice was investigated. Images of peritoneal tissues stained with these dyes and obtained through a confocal micro-endoscope are presented. Seventy-five Balb/c mice were split into five groups and given peritoneal injections of dye or saline. The proportions of negative outcomes in each group were compared using confidence intervals and the Fisher's exact statistical test. A statistically significant increase in adverse events due to dye injection was not observed. These data provide an initial investigation into the safety of acridine orange and SYTO 16 for in vivo imaging.
摘要
研究了腹腔注射吖啶橙和SYTO 16对小鼠的影响。展示了通过共聚焦微型内窥镜获得的用这些染料染色的腹膜组织图像。75只Balb/c小鼠被分成五组，腹腔注射染料或生理盐水。使用置信区间和Fisher精确统计检验比较每组的阴性结果比例。未观察到因注射染料导致的不良事件有统计学意义的增加。这些数据为吖啶橙和SYTO 16用于体内成像的安全性提供了初步研究。
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