Cognition and Neuroimaging Laboratories, Department of Psychology, University of Arizona, Tucson, Arizona, USA.
Hippocampus. 2010 Jan;20(1):11-8. doi: 10.1002/hipo.20607.
This study examined the involvement of medial temporal lobe, especially the hippocampus, in processing spatial and nonspatial relations using episodic and semantic versions of a relational judgment task. Participants studied object arrays and were tested on different types of relations between pairs of objects. Three prevalent views of hippocampal function were considered. Cognitive map theory (O'Keefe and Nadel (1978) The Hippocampus as a Cognitive Map. USA: Oxford University Press) emphasizes hippocampal involvement in spatial relational tasks. Multiple trace theory (Nadel and Moscovitch (1997) Memory consolidation, retrograde amnesia and the hippocampal complex Curr Opin Neurobiol 7:217-227) emphasizes hippocampal involvement in episodic tasks. Eichenbaum and Cohen's ((2001) From Conditioning to Conscious Recollection: Memory Systems of the Brain. USA: Oxford University Press) relational theory predicts equivalent hippocampal involvement in all relational tasks within both semantic and episodic memory. The fMRI results provided partial support for all three theories, though none of them fit the data perfectly. We observed hippocampal activation during all relational tasks, with increased activation for spatial compared to nonspatial relations, and for episodic compared to semantic relations. The placement of activation along the anterior-posterior axis of the hippocampus also differentiated the conditions. We suggest a view of hippocampal function in memory that incorporates aspects of all three theories.
本研究使用情节和语义关系判断任务的两种变体，考察了内侧颞叶（特别是海马体）在处理空间和非空间关系中的作用。参与者研究了物体数组，并接受了关于物体对之间不同类型关系的测试。考虑了三种流行的海马体功能观点。认知图理论（O'Keefe 和 Nadel（1978）《海马体作为认知图》。美国：牛津大学出版社）强调海马体在空间关系任务中的作用。多重痕迹理论（Nadel 和 Moscovitch（1997）《记忆巩固、逆行性遗忘和海马复合体》。当代神经生物学观点 7:217-227）强调海马体在情节任务中的作用。Eichenbaum 和 Cohen 的（2001）《从条件反射到有意识回忆：大脑的记忆系统》。美国：牛津大学出版社）的关系理论预测，在语义和情节记忆中，所有关系任务都需要海马体的同等参与。 fMRI 结果为所有三种理论提供了部分支持，但没有一种理论完全符合数据。我们观察到在所有关系任务中都有海马体激活，空间关系比非空间关系的激活更强，情节关系比语义关系的激活更强。海马体激活的位置沿着前后轴也区分了条件。我们提出了一种记忆中海马体功能的观点，该观点结合了三种理论的各个方面。
