Ricci S, Celani M G, La Rosa F, Vitali R, Duca E, Ferraguzzi R, Paolotti M, Seppoloni D, Caputo N, Chiurulla C
Perugia University Hospital, Italy.
J Neurol Neurosurg Psychiatry. 1991 Aug;54(8):695-8. doi: 10.1136/jnnp.54.8.695.
The SEPIVAC study is a community-based epidemiological survey of incidence and outcome of acute cerebrovascular disease in the Sixth Local Health Unit, Umbria, Italy (population 49,218). The study was carried out from 1 September 1986 to 31 August 1989. There were 375 patients who were registered with a first ever stroke, with a crude rate of 2.54 (95% confidence limits 2.29-2.81) per 1000 per year; the rate adjusted to the European population is 1.55 (CL 1.36-1.77). The age adjusted relative risk for males is 1.35 (CL 1.10-1.66). Up to 15% of the patients were not admitted to hospital during the acute phase of their disease. At least 286 (76.3%, CL 72-80.6) of the cases were due to cerebral ischaemia; in 56 of these (19.6%, CL 15-24.2) a clinical diagnosis of lacunar ischaemia was made. The 30 day case fatality rate was 20.3% (CL 16.2-24.3); between one and six months 7.5% (CL 5-10.6) of patients died.
SEPIVAC研究是一项基于社区的流行病学调查，针对意大利翁布里亚第六地方卫生单位（人口49218）急性脑血管疾病的发病率和转归情况展开。该研究于1986年9月1日至1989年8月31日进行。共有375例首次发生卒中的患者登记在册，粗发病率为每年每1000人中有2.54例（95%置信区间2.29 - 2.81）；根据欧洲人口调整后的发病率为1.55例（置信区间1.36 - 1.77）。男性的年龄调整相对风险为1.35（置信区间1.10 - 1.66）。高达15%的患者在疾病急性期未入院治疗。至少286例（76.3%，置信区间72 - 80.6）病例是由于脑缺血所致；其中56例（19.6%，置信区间15 - 24.2）临床诊断为腔隙性缺血。30天病死率为20.3%（置信区间16.2 - 24.3）；在1至6个月期间，7.5%（置信区间5 - 10.6）的患者死亡。
