Sapientiae Institute, Educational and Research Center in Assisted Reproduction, São Paulo, Brazil.
Fertil Steril. 2010 Apr;93(6):1870-4. doi: 10.1016/j.fertnstert.2008.12.043. Epub 2009 May 5.
To evaluate the effect of male age on clinical outcomes of intracytoplasmic sperm injection (ICSI) cycles, according to sperm concentration.
Retrospective, observational study.
Assisted reproduction center.
PATIENT(S): The study included 1,024 couples undergoing ICSI cycles with fresh spermatozoa.
INTERVENTION(S): The influence of paternal age on ICSI outcomes of oligozoospermic and normozoospermic patients was evaluated.
MAIN OUTCOME MEASURE(S): Rates of high-quality embryos, pregnancy, implantation, and miscarriage were evaluated through linear logistic regression analyses.
RESULT(S): When the sperm concentration was abnormal, paternal age influenced implantation (regression coefficient value = -0.7009) and pregnancy rates (odds ratio = 0.95, 95% confidence interval 0.91-0.99). However, in normozoospermic patients, no influence of paternal age was observed on implantation (regression coefficient value = 0.0566) or pregnancy rates (odds ratio = 1.00, 95% confidence interval 0.97-1.03).
CONCLUSION(S): For couples in which the men are oligozoospermic, the implantation rate could be impaired by increased paternal age. In these couples, the chance of pregnancy decreased 5% for each year of paternal age. When men are normozoospermic, this effect is not observed.
根据精子浓度评估男性年龄对卵胞浆内单精子注射（ICSI）周期临床结局的影响。
回顾性观察性研究。
辅助生殖中心。
这项研究纳入了 1024 对接受新鲜精子 ICSI 周期的夫妇。
评估了父龄对少精子症和正常精子症患者 ICSI 结局的影响。
通过线性逻辑回归分析评估优质胚胎、妊娠、种植和流产率。
当精子浓度异常时，父龄影响种植（回归系数值=-0.7009）和妊娠率（比值比=0.95，95%置信区间 0.91-0.99）。然而，在正常精子症患者中，父龄对种植（回归系数值=0.0566）或妊娠率（比值比=1.00，95%置信区间 0.97-1.03）没有影响。
对于精子少精症的夫妇，增加的父龄可能会降低种植率。在这些夫妇中，父龄每增加 1 岁，妊娠的机会就会减少 5%。当男性正常精子症时，这种影响就不会出现。
