School of Clinical Medicine, Qingdao University, Qingdao, China.
Department of Obstetrics and Gynecology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong, China.
Front Endocrinol (Lausanne). 2024 Aug 29;15:1325523. doi: 10.3389/fendo.2024.1325523. eCollection 2024.
This study aimed to investigate the impact of paternal age > 40 years on clinical pregnancy and perinatal outcomes among patients undergoing fertilization treatment.
We selected 75 male patients (aged > 40 years) based on predefined inclusion and exclusion criteria. Propensity score matching was performed in a 1:3 ratio, resulting in a control group (aged ≤ 40 years) of 225 individuals. Various statistical tests, including the Mann-Whitney U test, Chi-square test, Fisher's exact test, and binary logistic regression, were used to analyze the association between paternal age and clinical outcomes.
We found no statistically significant differences in semen routine parameters, clinical pregnancy outcomes, and perinatal outcomes between paternal aged > 40 and ≤ 40 years. However, in the subgroup analysis, the live birth rate significantly decreased in those aged ≥ 45 compared to those aged 41-42 and 43-44 years (31.25% vs. 69.23% and 65%, respectively; all p < 0.05). Additionally, the clinical pregnancy rate was significantly lower among those aged ≥ 45 than among those aged 41-42 (43.75% vs. 74.36%; p=0.035).
Paternal age ≥ 45 years was associated with lower live birth and clinical pregnancy rates.
本研究旨在探讨父亲年龄>40 岁对接受受精治疗患者临床妊娠和围产结局的影响。
我们根据预设的纳入和排除标准选择了 75 名年龄>40 岁的男性患者。采用 1:3 的比例进行倾向评分匹配，得到对照组（年龄≤40 岁）225 人。采用曼-惠特尼 U 检验、卡方检验、Fisher 确切检验和二项逻辑回归等多种统计检验方法分析父亲年龄与临床结局之间的关系。
我们发现父亲年龄>40 岁和≤40 岁之间的精液常规参数、临床妊娠结局和围产结局没有统计学差异。然而，在亚组分析中，与年龄 41-42 岁和 43-44 岁相比，年龄≥45 岁的活产率显著降低（31.25%比 69.23%和 65%，均 P<0.05）。此外，年龄≥45 岁的患者临床妊娠率显著低于年龄 41-42 岁的患者（43.75%比 74.36%；P=0.035）。
父亲年龄≥45 岁与较低的活产率和临床妊娠率相关。
