耳叶凤仙花中的三萜皂苷

Triterpenoid saponins from Impatiens siculifer.

作者信息

Li Wei, Bi Xueyan, Wang Kun, Li Dongxia, Satou Tadaaki, Koike Kazuo

机构信息

Faculty of Pharmaceutical Sciences, Toho University, Funabashi, Chiba 274-8510, Japan.

出版信息

Phytochemistry. 2009 Apr;70(6):816-21. doi: 10.1016/j.phytochem.2009.03.022. Epub 2009 May 4.

DOI:10.1016/j.phytochem.2009.03.022

PMID:19409580

Abstract

Triterpenoid saponins, impatienosides A-G, together with 12 known saponins, were isolated from the whole plants of Impatiens siculifer. Their structures were established on the basis of extensive 1D and 2D NMR and MS analyses coupled with chemical degradation. Cytotoxic activities of the isolated saponins were evaluated against three human cancer cell lines: human myeloid leukemia HL-60 cells, human stomach KATO-III adenocarcinoma, and human lung A549 adenocarcinoma.

摘要

从耳叶凤仙（Impatiens siculifer）全草中分离得到了三萜皂苷——凤仙皂苷A - G，以及12种已知皂苷。通过广泛的一维和二维核磁共振（NMR）以及质谱（MS）分析，并结合化学降解方法确定了它们的结构。对分离得到的皂苷针对三种人类癌细胞系进行了细胞毒性活性评估：人髓性白血病HL - 60细胞、人胃KATO - III腺癌以及人肺A549腺癌。