Gethmann J, Hüttner K, Heyne H, Probst C, Ziller M, Beer M, Hoffmann B, Mettenleiter T C, Conraths F J
Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Institute of Epidemiology, Seestrasse 55, 16868 Wusterhausen, Germany.
Vaccine. 2009 Jun 24;27(31):4118-26. doi: 10.1016/j.vaccine.2009.04.072. Epub 2009 May 15.
After massive epidemics of bluetongue disease in 2006 and 2007, Germany has started a compulsory vaccination program against bluetongue virus serotype 8 (BTV-8). Since the available vaccines had not yet been registered and only limited data were available on their performance, a safety study was conducted with three different inactivated monovalent vaccines under consideration for use in Germany. A total of 1007 sheep and 893 cattle were vaccinated and subsequently compared with 638 control animals (324 sheep and 314 cattle). During the study, all animals remained in good health condition. After the initial immunisation, only local swellings were observed in a small number of animals. Following revaccination, several sheep developed more distinct local reactions and a temporary rise in body temperature. Severe systemic reactions were not detected in any of the study groups. Among cattle, neither fever, nor a decrease in milk production and only temporary low-grade local reactions were observed. Overall, our results demonstrate a high level of safety of all vaccines tested.
在2006年和2007年蓝舌病大规模流行之后，德国启动了针对蓝舌病毒8型（BTV-8）的强制疫苗接种计划。由于可用疫苗尚未注册，且关于其性能的数据有限，因此对三种不同的灭活单价疫苗进行了安全性研究，这些疫苗正在考虑在德国使用。总共对1007只绵羊和893头牛进行了疫苗接种，随后与638只对照动物（324只绵羊和314头牛）进行了比较。在研究期间，所有动物健康状况良好。初次免疫后，仅在少数动物中观察到局部肿胀。再次接种疫苗后，几只绵羊出现了更明显的局部反应和体温暂时升高。在任何研究组中均未检测到严重的全身反应。在牛中，既未观察到发热，也未观察到产奶量下降，仅观察到暂时的轻度局部反应。总体而言，我们的结果表明所有测试疫苗的安全性都很高。
