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致病原生动物内吞途径的电子显微镜和细胞化学分析

Electron microscopy and cytochemistry analysis of the endocytic pathway of pathogenic protozoa.

作者信息

de Souza Wanderley, Sant'Anna Celso, Cunha-e-Silva Narcisa L

机构信息

Laboratório de Ultraestrutura Celular Hertha Meyer, Instituto de Biofísica Carlos Chagas Filho, Universidade Federal do Rio de Janeiro, Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21941-902, Brazil.

出版信息

Prog Histochem Cytochem. 2009;44(2):67-124. doi: 10.1016/j.proghi.2009.01.001. Epub 2009 Apr 5.

DOI:10.1016/j.proghi.2009.01.001
PMID:19410686
Abstract

Endocytosis is essential for eukaryotic cell survival and has been well characterized in mammal and yeast cells. Among protozoa it is also important for evading from host immune defenses and to support intense proliferation characteristic of some life cycle stages. Here we focused on the contribution of morphological and cytochemical studies to the understanding of endocytosis in Trichomonas, Giardia, Entamoeba, Plasmodium, and trypanosomatids, mainly Trypanosoma cruzi, and also Trypanosoma brucei and Leishmania.

摘要

内吞作用对于真核细胞的存活至关重要,并且在哺乳动物和酵母细胞中已得到充分表征。在原生动物中,它对于逃避宿主免疫防御以及支持某些生命周期阶段特有的强烈增殖也很重要。在这里,我们重点关注形态学和细胞化学研究对理解毛滴虫、贾第虫、溶组织内阿米巴、疟原虫和锥虫(主要是克氏锥虫,还有布氏锥虫和利什曼原虫)内吞作用的贡献。

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