INSERM, ERI 25-Muscle et Pathologies, Hôpital Arnaud de Villeneuve, Bât. A Craste de Paulet, 34295 Montpellier Cedex 5, France.
Curr Genomics. 2007 Nov;8(7):415-22. doi: 10.2174/138920207783591672.
Myostatin is an endogenous, negative regulator of muscle growth determining both muscle fiber number and size. The myostatin pathway is conserved across diverse species ranging from zebrafish to humans. Experimental models of muscle growth and regeneration have implicated myostatin as an important mediator of catabolic pathways in muscle cells. Inhibition of this pathway has emerged as a promising therapy for muscle wasting. Here we discuss the recent developments and the controversies in myostatin research, focusing on the molecular and cellular mechanisms underlying the actions of myostatin on skeletal muscle and the potential therapeutic role of myostatin on muscle-related disorders.
肌肉生长抑制素是一种内源性的肌肉生长负调控因子，决定肌肉纤维的数量和大小。肌肉生长抑制素途径在从斑马鱼到人等多种物种中是保守的。肌肉生长和再生的实验模型表明，肌肉生长抑制素是肌肉细胞中分解代谢途径的重要介质。抑制这条途径已成为治疗肌肉消耗的一种有前途的方法。在这里，我们讨论肌肉生长抑制素研究的最新进展和争议，重点介绍肌肉生长抑制素对骨骼肌作用的分子和细胞机制，以及肌肉生长抑制素在肌肉相关疾病中的潜在治疗作用。
