Nammi Srinivas, Sreemantula Satyanarayana, Roufogalis Basil D
Herbal Medicines Research and Education Centre, Faculty of Pharmacy, University of Sydney, Sydney, NSW 2006, Australia.
Basic Clin Pharmacol Toxicol. 2009 May;104(5):366-73. doi: 10.1111/j.1742-7843.2008.00362.x.
Metabolic syndrome, including obesity, dyslipidaemia, hyperglycaemia and insulin resistance that predisposes type 2 diabetes is a major disease problem around the world and a plethora of herbal medicines are claimed to be effective in controlling these disorders. The rhizome of Zingiber officinale (Zingiberaceae) is commonly used as a spice in various foods and beverages. Apart from its other traditional medical uses, Z. officinale has been used to control diabetes and dyslipidaemia. In the present study, the protective effects of an ethanolic extract of Z. officinale on the development of metabolic syndrome were investigated in a high-fat diet-fed rat model at doses of 100, 200 and 400 mg/kg body weight. The marked rise in body weights, glucose, insulin, total cholesterol, LDL cholesterol, triglycerides, free fatty acids and phospholipids in serum of the rats that followed 6 weeks of high-fat diet treatment were significantly reduced by Z. officinale treatment. However, no significant change in serum HDL cholesterol was observed either with high-fat diet or Z. officinale compared to both control groups. The present results provide scientific evidence to substantiate the traditional use of Z. officinale in preventing metabolic disorders.
代谢综合征，包括肥胖、血脂异常、高血糖和胰岛素抵抗（这些因素会诱发2型糖尿病）是全球主要的疾病问题，大量草药据称对控制这些病症有效。姜科植物姜的根茎在各种食品和饮料中常用作香料。除了其他传统医学用途外，姜还被用于控制糖尿病和血脂异常。在本研究中，以100、200和400毫克/千克体重的剂量，在高脂饮食喂养的大鼠模型中研究了姜乙醇提取物对代谢综合征发展的保护作用。经过6周高脂饮食处理的大鼠血清中体重、葡萄糖、胰岛素、总胆固醇、低密度脂蛋白胆固醇、甘油三酯、游离脂肪酸和磷脂的显著升高，经姜处理后显著降低。然而，与两个对照组相比，高脂饮食组或姜处理组的血清高密度脂蛋白胆固醇均未观察到显著变化。目前的结果提供了科学证据，证实了姜在预防代谢紊乱方面的传统用途。
