Prealbumin content of cerebrospinal fluid and sera in persons with multiple sclerosis.

The prealbumin content of cerebrospinal fluid (CSF) and serum of patients with multiple sclerosis (MS) was determined. Prealbumin was determined, quantitatively in unconcentrated CSF and serum by Laurell's rocket immunoelectrophoresis. The values of serum prealbumin content were normal. An increased prealbumin content was found in the CSF of patients. With other laboratory examinations, the increased CSF prealbumin content may contribute to the diagnosis of MS.