基于胶体纳米信标的分子光声断层成像
Molecular photoacoustic tomography with colloidal nanobeacons.
作者信息
Pan Dipanjan, Pramanik Manojit, Senpan Angana, Yang Xinmai, Song Kwang H, Scott Mike J, Zhang Huiying, Gaffney Patrick J, Wickline Samuel A, Wang Lihong V, Lanza Gregory M
机构信息
C-TRAIN and Division of Cardiology, Washington University School of Medicine, 4320 Forest Park Avenue, Saint Louis, MO 63108, USA.
出版信息
Angew Chem Int Ed Engl. 2009;48(23):4170-3. doi: 10.1002/anie.200805947.
Abstract
Spotting clots: Vascularly constrained colloidal gold nanobeacons (GNBs; see picture) can be used as exogenous photoacoustic contrast agents for the targeted detection of fibrin, a major biochemical feature of thrombus. Fibrin-targeted GNBs provide a more than tenfold signal enhancement in photoacoustic tomography in the near-IR wavelength window, indicating their potential for diagnostic imaging.
摘要
发现血栓
血管受限的胶体金纳米信标（GNBs；见图）可作为外源性光声造影剂，用于靶向检测纤维蛋白，这是血栓的一个主要生化特征。靶向纤维蛋白的GNBs在近红外波长窗口的光声断层成像中可提供超过十倍的信号增强，表明其在诊断成像方面的潜力。
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